Mapping brain glutamate in humans: sex differences in cigarette smokers

绘制人类大脑谷氨酸图谱:吸烟者的性别差异

基本信息

  • 批准号:
    10376214
  • 负责人:
  • 金额:
    $ 7.8万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-04-01 至 2023-03-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY/ABSTRACT Smoking is the leading cause of preventable death and disease in the U.S. Women are disproportionately affected by smoking, as they not only have a higher risk of experiencing some health consequences of smoking, such as heart disease, but also suffer sex-specific health issues, including cervical cancer. Women have more difficulty maintaining long-term abstinence from smoking than men, possibly because they experience stronger withdrawal symptoms and greater relief of these symptoms after resumption of smoking. Despite their enhanced need for smoking-cessation therapies, current first-line treatments, such as nicotine replacement, are less effective for women than men. The underlying differences in brain function that drive these sex differences remain unknown, and understanding them can guide development of personalized smoking cessation therapies. Glutamatergic neurotransmission is a promising new target for smoking cessation therapy, but sex differences in glutamate levels across the brain, which can impact the efficacy of glutamatergic treatments, have not been investigated in smokers. Our preliminary data using single-voxel magnetic resonance spectroscopy (MRS), have revealed important sex differences in the relationships of glutamate in the dorsal anterior cingulate cortex (dACC), a region highly implicated in Tobacco Use Disorder, with sex (males vs. females) and smoking state (overnight abstinent vs. post-smoking) in smokers. Moreover, glutamate in the dACC is also associated with circulating estrogen, and possibly progesterone, in women who smoke. However, important relationships between glutamate in other brain regions and these factors are yet to be explored. Echo-planar spectroscopic imaging (EPSI), a state-of-the-art technique, permits measurement of glutamate in ~80 percent of the whole brain in vivo in humans. Given our preliminary results using single-voxel MRS, we now propose to test replicability of our finding in the dACC and to examine potential extension to other brain regions heavily implicated in the behavioral states of Tobacco Use Disorder - the anterior insula and thalamus. We will also perform exploratory analyses of relationships of glutamate across the brain with sex, smoking state, and ovarian hormones. Otherwise healthy, adult daily smokers (30 men and 30 women) will serve as participants for this study. They will be tested twice, after overnight (~12 h) abstinence from smoking and after smoking their first cigarette of the day. We will combine EPSI with analysis of circulating ovarian hormones in serum to address two specific aims: Aim 1. Determine relationships between brain glutamate, sex, and circulating ovarian hormones. Aim 2. Determine sex differences in acute effects of smoking on brain glutamate. The findings from this study will provide important empirical information regarding glutamate levels across the brain in smokers and help guide development of personalized, sex-specific smoking cessation therapies.
项目总结/文摘

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Jeffry R Alger其他文献

Jeffry R Alger的其他文献

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{{ truncateString('Jeffry R Alger', 18)}}的其他基金

Novel Algorithms for Reducing Radiation Dose of CT Perfusion
减少 CT 灌注辐射剂量的新算法
  • 批准号:
    10220967
  • 财政年份:
    2017
  • 资助金额:
    $ 7.8万
  • 项目类别:
Novel Algorithms for Reducing Radiation Dose of CT Perfusion
减少 CT 灌注辐射剂量的新算法
  • 批准号:
    10006737
  • 财政年份:
    2017
  • 资助金额:
    $ 7.8万
  • 项目类别:
VALIDATION OF MAGNETIC RESONANCE PERFUSION IMAGING
磁共振灌注成像的验证
  • 批准号:
    6193264
  • 财政年份:
    2000
  • 资助金额:
    $ 7.8万
  • 项目类别:
VALIDATION OF MAGNETIC RESONANCE PERFUSION IMAGING
磁共振灌注成像的验证
  • 批准号:
    6394294
  • 财政年份:
    2000
  • 资助金额:
    $ 7.8万
  • 项目类别:
VALIDATION OF MAGNETIC RESONANCE PERFUSION IMAGING
磁共振灌注成像的验证
  • 批准号:
    6603227
  • 财政年份:
    2000
  • 资助金额:
    $ 7.8万
  • 项目类别:
VALIDATION OF MAGNETIC RESONANCE PERFUSION IMAGING
磁共振灌注成像的验证
  • 批准号:
    6540203
  • 财政年份:
    2000
  • 资助金额:
    $ 7.8万
  • 项目类别:
RESEARCH ANIMAL MAGNETIC RESONANCE IMAGING INSTRUMENT
研究动物磁共振成像仪
  • 批准号:
    2864968
  • 财政年份:
    1999
  • 资助金额:
    $ 7.8万
  • 项目类别:
PEDIATRIC LOW GRADE ASTROCYTOMA--TREATMENT GUIDANCE
儿童低度星形细胞瘤——治疗指南
  • 批准号:
    2837789
  • 财政年份:
    1997
  • 资助金额:
    $ 7.8万
  • 项目类别:
PEDIATRIC LOW GRADE ASTROCYTOMA--TREATMENT GUIDANCE
儿童低度星形细胞瘤——治疗指南
  • 批准号:
    2461212
  • 财政年份:
    1997
  • 资助金额:
    $ 7.8万
  • 项目类别:

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