RESEARCH ANIMAL MAGNETIC RESONANCE IMAGING INSTRUMENT

研究动物磁共振成像仪

• 批准号: 2864968
• 负责人: Jeffry R Alger
• 金额: $ 40万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-15 至 2003-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2864968
• 关键词: bioimaging /biomedical imaging; biomedical equipment; biomedical equipment purchase; magnetic resonance imaging; nuclear magnetic resonance spectroscopy

The project aim is to establish a magnetic resonance imaging (MRI) laboratory within the UCLA School of Medicine. The laboratory will house and operate a 4.7 Tesla magnetic resonance imaging scanner with a 40 cm clear bore diameter that is specifically designed for investigational studies of research animals. The instrument will be capable of performing a wide variety of magnetic resonance imaging and spectroscopic studies which are collectively referred at as "functional" MRI in addition to performing high resolution anatomic imaging. No instrument of this sort exists at UCLA, nor have UCLA investigators have had access to one, although some related studies have been performed on clinical service MRI scanners. However, the project will be guided by a Principal Investigator who has over a dozen years of experience with the management and use of similar instruments at other institutions. The UCLA School of Medicine houses a high concentration of federally- supported research studies. The proposal describes twelve federal grants which are now underway at UCLA which require the proposed instrument. Ten of these are research grants. Two are training grants The federal research grants include a variety of basic and health-related aims. Hence, the facility will serve as a research resource for UCLA investigators whose research requires functional and anatomic imaging of animal models being studied in their own laboratories under federal sponsorship. Neuroscience and gene therapy will be broad focuses of the biological imaging studies which are undertaken once the facility is established. However, in the long term, a fluid and evolving biological research focus is anticipated in consistency with the "resource" function in the laboratory. The vendor's listed instrument cost including needed accessories is over $1 million. The cost together with the combined basic and health-related goals make the project eligible for dual agency (NCRR and NSF) consideration. Funding at the maximum level from both agencies is thereby requested.

该项目的目标是在加州大学洛杉矶分校医学院建立一个磁共振成像（MRI）实验室。该实验室将容纳并操作一台4.7特斯拉磁共振成像扫描仪，其净孔径为40 cm，专为研究动物的研究性研究而设计。该仪器将能够执行各种磁共振成像和光谱研究，这些研究统称为“功能性”MRI，此外还能够执行高分辨率解剖成像。加州大学洛杉矶分校没有这种仪器，加州大学洛杉矶分校的研究人员也没有接触到这种仪器，尽管已经对临床服务MRI扫描仪进行了一些相关研究。然而，该项目将由一名主要研究者指导，该研究者在其他机构管理和使用类似仪器方面拥有十几年的经验。加州大学洛杉矶分校医学院拥有高度集中的联邦政府支持的研究。该提案描述了12个联邦赠款，目前正在加州大学洛杉矶分校进行，需要拟议的文书。其中10项是研究赠款。两项是培训赠款金。联邦研究赠款包括各种基本和与健康有关的目标。因此，该设施将作为加州大学洛杉矶分校研究人员的研究资源，他们的研究需要在联邦赞助下在他们自己的实验室中研究的动物模型的功能和解剖成像。神经科学和基因治疗将是生物成像研究的广泛焦点，一旦该设施建立，将进行这些研究。然而，从长远来看，一个流动的和不断变化的生物学研究的重点，预计在实验室的“资源”功能一致。供应商列出的仪器成本（包括所需的配件）超过100万美元。该项目的成本以及基本目标和与健康有关的目标使其有资格获得两个机构（国家康复和康复委员会和国家科学基金会）的审议。因此，要求这两个机构提供最高数额的资金。