VALIDATION OF MAGNETIC RESONANCE PERFUSION IMAGING

磁共振灌注成像的验证

• 批准号: 6540203
• 负责人: Jeffry R Alger
• 金额: $ 32.58万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-25 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6540203
• 关键词: bioimaging /biomedical imaging; cerebrovascular imaging /visualization; clinical research; diagnosis design /evaluation; diagnosis quality /standard; human subject; magnetic resonance imaging; perfusion; positron emission tomography; stroke

DESCRIPTION (Adapted from Applicant's Abstract): The aim is to optimize and validate the Magnetic Resonance Imaging (MRI) bolus passage perfusion technique in stroke victims. Recently discovered perfusion/diffusion MRI techniques are among the most promising developments in acute stroke care in this decade because they can potentially distinguish the ischemic core from surrounding hypoperfused but salvageable tissue. At present, the weakest component of the acute stroke MRI study is the perfusion study. There has been no direct demonstration that perfusion MRI accurately detects penumbral hypoperfusion by comparison with a "gold standard" method in stroke patients. No team has defined a recipe of optimal perfusion scanning parameters and then validated this recipe in stroke victims against a gold standard. There has been no direct validation of the usually-made assumption of a log-linear relationship between intravascular contrast agent concentration and MRI signal change. Likewise, no proven data analysis recipe has come forth. Oxygen-15 water Positron Emission Tomography (PET) blood flow assessment will be used as gold standard to validate perfusion MRI studies of stroke victims. MRI and PET assessment of blood flow will be made back-to-back. Medically stable stroke patients in the subacute epoch (< 48 hrs) will be studied. These patients are expected to display a wide range of blood flow values which will provide a high dynamic range over which to test the accuracy of perfusion MRI, yet be stable enough to undergo both studies. MRI perfusion scans using different MRI scanning parameters and analysis methods will be evaluated against the PET gold standard. Using the validated MRI procedures, a further pilot study is planned to explore whether MRI can accurately identify perfusion abnormalities and cerebrovascular reserve deficiencies in asymptotic subjects who have vascular risk factors for stroke. UCLA has new state-of-the-art MRI and PET imaging devices together with active collaborating teams having expertise in stroke clinical management (both acute and rehabilitative), in MRI scanning and in PET scanning.

描述（根据申请人的摘要改编）：目的是优化和 验证磁共振成像（MRI）推注通道灌注技术 在中风受害者中。最近发现的灌注/扩散MRI技术是 这十年来最有前途的急性中风护理发展 因为它们可以将缺血核与周围区分开 屈曲但可以挽救的组织。目前，是 急性中风MRI研究是灌注研究。没有直接 证明灌注MRI准确地检测到通过 与中风患者的“黄金标准”方法进行比较。没有团队 定义了最佳灌注扫描参数的配方，然后验证 这种违反黄金标准的中风受害者的食谱。没有直接 验证通常建立的对数线性关系的假设 血管内造影剂浓度和MRI信号变化。同样，不 经过验证的数据分析配方已经出现。氧气-15水位发射 层析成像（PET）血流评估将用作黄金标准 验证中风受害者的灌注MRI研究。 MRI和宠物评估 血流将背靠背。医学稳定的中风患者 将研究亚急性时期（<48小时）。这些患者有望 显示广泛的血流值，这将提供高动态 范围可以测试灌注MRI的准确性，但足够稳定以至于 两项研究。 MRI灌注扫描使用不同的MRI扫描 参数和分析方法将针对PET黄金进行评估 标准。使用经过验证的MRI程序，计划了进一步的试点研究 探索MRI是否可以准确识别灌注异常和 具有血管的渐近受试者的脑血管储备不足 中风的风险因素。加州大学洛杉矶分校拥有新的最先进的MRI和宠物成像 设备以及具有中风专业知识的积极合作团队 MRI扫描和PET中的临床管理（急性和康复） 扫描。