eLIXIR, Early Lifecourse data Cross-LInkage in Research; a Multidisciplinary Partnership

eLIXIR，早期生命历程数据交叉链接研究；

• 批准号: MR/P003060/1
• 负责人: Lucilla Poston
• 金额: $ 110.52万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FP003060%2F1
• 关键词: eLIXIR; Early; Lifecourse; data; Cross

The developing embryo, fetus and newborn child are very sensitive to change in the surrounding environment, whether this arises from problems with the mother's health, the placenta not working properly, complications during birth, or as consequence of being born too early. Adversity in these periods of developmental vulnerability can have persistent effects on the long term health of the child, including physical and mental health disorders. We also know that if a mother has complications in pregnancy, that she may suffer from increased risk of ill-heath in later life, for example cardiovascular disease, diabetes or mental health problems. To reduce the risk of these diseases in the child and in the mother, we need to know more about the processes leading up to them. One approach is to capture the information from hospital and general practice health care records as the child grows up, or as the mother gets older, and through the study of this data and routinely collected blood samples, work out when and why the disorders happen. When we know this, we shall be able to work out how to prevent them. In England routine health records are held in different computer systems and are not easy to assemble. Our partnership, the eLIXIR partnership of doctors, scientists and IT specialists has developed a way to put all this data together and to collect it continuously. We shall start doing this in a large population from a deprived area of South London, where health is poor compared to other areas of England. When we have shown this system works, we plan to extend the study to a much bigger population in London and elsewhere. This new and important research resource will help us explore the 'life course' of some of the most common diseases, and help scientists and doctors to work out how we may prevent them.

发育中的胚胎、胎儿和新生儿对周围环境的变化非常敏感，无论这是由于母亲的健康问题、胎盘不能正常工作、出生时的并发症，还是由于过早出生。在这些发育脆弱时期的逆境可能对儿童的长期健康产生持久影响，包括身心健康障碍。我们还知道，如果母亲在怀孕期间有并发症，她在以后的生活中可能会增加患疾病的风险，例如心血管疾病，糖尿病或精神健康问题。为了减少儿童和母亲患这些疾病的风险，我们需要更多地了解导致这些疾病的过程。一种方法是随着孩子的成长或母亲年龄的增长，从医院和全科医疗保健记录中获取信息，并通过研究这些数据和定期收集的血液样本，找出疾病发生的时间和原因。当我们知道这一点时，我们将能够研究如何防止它们。在英国，日常的健康记录保存在不同的计算机系统中，不容易汇集。我们的合作伙伴关系，医生，科学家和IT专家的eLIXIR合作伙伴关系已经开发出一种将所有这些数据放在一起并持续收集的方法。我们将在伦敦南部贫困地区的大量人口中开始这样做，与英格兰其他地区相比，那里的健康状况很差。当我们证明这个系统有效时，我们计划将研究扩展到伦敦和其他地方的更大人口。这一新的重要研究资源将帮助我们探索一些最常见疾病的“生命历程”，并帮助科学家和医生研究如何预防它们。

项目成果

An evaluation of symptom domains in the 2 years before pregnancy as predictors of relapse in the perinatal period in women with severe mental illness.

• DOI: 10.1192/j.eurpsy.2021.18
• 发表时间: 2021-03-19
• 期刊: European psychiatry : the journal of the Association of European Psychiatrists
• 作者: Khapre S;Stewart R;Taylor C
• 通讯作者: Taylor C

Changes in the identification and management of mental health and domestic abuse among pregnant women during the COVID-19 lockdown: regression discontinuity study.

• DOI: 10.1192/bjo.2022.66
• 发表时间: 2022-06-03
• 期刊: BJPSYCH OPEN
• 影响因子: 5.4
• 作者: Hildersley, Rosanna;Easter, Abigail;Bakolis, Ioannis;Carson, Lauren;Howard, Louise M.
• 通讯作者: Howard, Louise M.

Trends in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and vaccine antibody prevalence in a multi-ethnic inner-city antenatal population: A cross-sectional surveillance study.

• DOI: 10.1111/1471-0528.17508
• 发表时间: 2023-08
• 期刊: BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
• 影响因子: 5.8
• 作者: Andreeva, Daria;Gill, Carolyn;Brockbank, Anna;Hejmej, Joanna;Conti-Ramsden, Fran J.;Doores, Katie T.;Seed, Paul;Poston, Lucilla
• 通讯作者: Poston, Lucilla

Cohort profile: the eLIXIR Partnership-a maternity-child data linkage for life course research in South London, UK.

• DOI: 10.1136/bmjopen-2020-039583
• 发表时间: 2020-10-06
• 期刊: BMJ open
• 影响因子: 2.9
• 作者: Carson LE;Azmi B;Jewell A;Taylor CL;Flynn A;Gill C;Broadbent M;Howard L;Stewart R;Poston L;eLIXIR Partnership
• 通讯作者: eLIXIR Partnership