Dietary induced predictive adapted responses causing metabolic syndrome

饮食诱导的预测性适应反应导致代谢综合征

• 批准号: BB/D522246/1
• 负责人: Lucilla Poston
• 金额: $ 17.51万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FD522246%2F1
• 关键词: Dietary; induced; predictive; adapted; responses

If a pregnant woman eats a healthy diet the developing baby would be expected to develop normally in most pregnancies. We suggest that providing the developing baby, child and then adult continues to eat a healthy diet throughout life, the risk of adult diabetes and heart disease will be low. We reason that in the womb the healthy diet allows the baby to develop a normal metabolism and that this baby¿s metabolism is primed to cope with a healthy diet also in childhood and adulthood. The risk of this person developing adult diabetes and heart disease later in life is very, very low. However if the baby is not brought up after birth and throughout childhood to eat a healthy diet, but eats instead a diet rich in fat, the baby¿s metabolism is now not able to cope with this diet, because in the womb it had never been exposed to these foods. We reason that this occurs because during development in the womb the baby was never exposed to unhealthy foods and therefore its metabolism did not develop to cope. When this child eats these unhealthy foods in childhood and then in adulthood because its metabolism has not developed to cope there is a marked increase in that person developing adult diabetes and heart disease. Therefore it is very important to study the effect of the combination of the pre-natal and the post-natal diets. We argue that where there is imbalance, or large differences, between these diets the effects on the offspring can be severe and risk of adult disease and heart disease later in life increases considerably. Only by choosing an animal model is it possible to study this phenomenon, because it is necessary to change both the pre- and post-natal diets and it would be unethical to undertake these changes in pregnant mothers and their babies. It is our intention of undertaking this study using a rodent model. Joint with BB/D001633/1.

如果孕妇吃健康的饮食，发育中的婴儿在大多数怀孕期间都会正常发育。我们建议，提供发展中的婴儿，儿童，然后成人继续吃健康的饮食在整个生命，风险成人糖尿病和心脏病将是低的。我们的理由是，在子宫中，健康的饮食可以让婴儿发展正常的新陈代谢，而这个婴儿的新陈代谢也可以在童年和成年时科普健康的饮食。这个人在以后的生活中患上成人糖尿病和心脏病的风险非常非常低。然而，如果婴儿出生后没有在整个童年时期吃健康的饮食，而是吃富含脂肪的饮食，婴儿的新陈代谢现在无法科普这种饮食，因为在子宫里它从未接触过这些食物。我们的理由是，发生这种情况是因为在子宫内发育期间，婴儿从未接触过不健康的食物，因此其新陈代谢没有发展到科普。当这个孩子在童年吃这些不健康的食物，然后在成年后，因为它的新陈代谢没有发展到科普有一个显着增加的人发展成人糖尿病和心脏病。因此，研究产前和产后饮食组合的效果非常重要。我们认为，如果这些饮食之间存在不平衡或较大差异，对后代的影响可能会很严重，成年疾病和心脏病的风险会大大增加。只有通过选择动物模型才有可能研究这种现象，因为有必要改变产前和产后的饮食，而对孕妇及其婴儿进行这些改变是不道德的。我们打算使用啮齿动物模型进行本研究。与BB/D 001633/1接合。