The UPBEAT RCT mother-child study. Stratifying and treating obese pregnant women to prevent adverse pregnancy, perinatal and longer term outcomes.

UPBEAT RCT 母子研究。

• 批准号: MR/L002477/1
• 负责人: Lucilla Poston
• 金额: $ 107.31万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FL002477%2F1
• 关键词: UPBEAT; RCT; mother; child; study.

In the UK almost one in five women are obese when they become pregnant. Whilst many of these women will have quite normal pregnancies there is a greater than average risk that the mother and her baby will develop complications. Diabetes is the most common, and even when treated it can make the baby grow too large which leads to problems at delivery. Obese women are also more prone to a disorder known as pre-eclampsia which can be very serious, and often leads to doctors having to deliver the baby before its due date. At present we do not have a complete picture of what causes these and other problems. In this study we are going to measure some specific chemicals in the blood of obese pregnant women, which our previous studies suggest may be important for causing these complications. We are also going to use a new and very accurate laboratory technique, known as metabolomics, which provides an overview of 216 different measures, to try to identify other novel chemicals that are responsible. We shall find out how the levels of these chemicals in the blood are related to development of the different complications. When we understand more about these relationships we hope we shall be able to develop better tests and treatments. In this study, one of our aims is to develop tests in early pregnancy that will be accurate enough to tell us which obese women will not have any problems in pregnancy and which women doctors and midwives will need to give more attention to in order to ensure they have the best possible chance of a healthy pregnancy.This research will be made possible by a large study of more than 1500 women, called UPBEAT. The aim of UPBEAT it to find out whether fewer complications occur when obese mothers are helped to improve their diet and engage in more physical activity. UPBEAT is taking place in more than ten hospitals in the UK and will finish in 2014. Half of the pregnant women get special dietary and physical activity advice from health trainers from early on in their pregnancy, and the other half have normal antenatal care. The participants are providing blood samples at different times during their pregnancy which we will use for this study; not only will these help us to find out about the causes of the complications but it will be very interesting to see whether the blood chemical profile in women who have been helped to change their lifestyle is better than women who have had normal care.Lastly, it is currently thought that babies born to obese mothers are more likely to become obese in childhood than babies born to thinner mothers. This is because if babies are exposed in the very earliest stage of life, i.e. in the womb, to the altered blood chemical levels of their mothers, that they are permanently affected. They are then likely to put on more weight and become obese children and adults. We have been funded to measure the fatness of the three year old children of the UPBEAT mothers, as well as their diet and physical activity. This is called the UPBEAT TEMPO study. By combining UPBEAT and UPBEAT TEMPO we will have a unique opportunity to determine whether the levels of the chemicals in the mother's blood in pregnancy are related to the levels of fatness in the children. Even more important is that we will also be able to determine whether the children of the mothers who changed their lifestyle during pregnancy are thinner. If we find out that there are chemical links between obesity in the mother and the development of obesity in her child that will be a major step in helping us work out new ways of helping to prevent obesity in children.

在英国，几乎五分之一的女性在怀孕时肥胖。虽然这些妇女中的许多人会有相当正常的怀孕，但母亲和婴儿患并发症的风险高于平均水平。糖尿病是最常见的，即使在治疗时，它也会使婴儿长得太大，导致分娩时出现问题。肥胖妇女也更容易患上一种被称为先兆子痫的疾病，这种疾病可能非常严重，往往导致医生不得不在预产期前分娩。目前，我们对这些问题和其他问题的原因还没有一个完整的了解。在这项研究中，我们将测量肥胖孕妇血液中的一些特定化学物质，我们以前的研究表明这些化学物质可能对导致这些并发症很重要。我们还将使用一种新的非常精确的实验室技术，称为代谢组学，它提供了216种不同测量方法的概述，试图确定其他负责的新化学物质。我们将了解血液中这些化学物质的水平如何与不同并发症的发展相关。当我们对这些关系有更多的了解时，我们希望能够开发出更好的测试和治疗方法。在这项研究中，我们的目标之一是开发怀孕早期的测试，这些测试将足够准确地告诉我们哪些肥胖女性在怀孕期间不会有任何问题，哪些女性医生和助产士需要给予更多的关注，以确保她们有最好的机会健康怀孕。这项研究将通过一项超过1500名女性的大型研究成为可能，称为UPBEAT。UBEAT的目的是找出当肥胖母亲得到帮助改善饮食和从事更多体育活动时是否会减少并发症的发生。UBEAT正在英国的十多家医院进行，将于2014年结束。一半的孕妇在怀孕早期就得到健康培训师的特殊饮食和体育活动建议，另一半则得到正常的产前护理。受试者在妊娠期间的不同时间提供血样，我们将用于本研究;这不仅有助于我们找出并发症的原因，而且还有助于我们了解接受帮助改变生活方式的妇女的血液化学特征是否优于接受正常护理的妇女。最后，目前认为，肥胖母亲所生的婴儿在童年时期比较瘦母亲所生的婴儿更有可能变得肥胖。这是因为，如果婴儿在生命的最早阶段，即在子宫中，暴露于母亲血液化学水平的改变，他们会受到永久性的影响。然后他们可能会增加更多的体重，成为肥胖的儿童和成人。我们获得资助来测量UPBEAT母亲的三岁孩子的肥胖程度，以及他们的饮食和身体活动。这就是所谓的UBEAT克里思研究。通过结合UBEAT和UBEAT克里思，我们将有一个独特的机会来确定怀孕期间母亲血液中的化学物质水平是否与儿童的肥胖水平有关。更重要的是，我们还将能够确定在怀孕期间改变生活方式的母亲的孩子是否更瘦。如果我们发现母亲的肥胖和孩子的肥胖之间存在化学联系，这将是帮助我们找到预防儿童肥胖的新方法的重要一步。

项目成果

External validation of prognostic models to predict stillbirth using International Prediction of Pregnancy Complications (IPPIC) Network database: individual participant data meta-analysis.

使用国际妊娠并发症预测 (IPPIC) 网络数据库对预测死产的预后模型进行外部验证：个体参与者数据荟萃分析。

• DOI: 10.1002/uog.23757
• 发表时间: 2022
• 期刊: the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
• 作者: Allotey J

Modifiable Determinants of Postpartum Weight Loss in Women with Obesity: A Secondary Analysis of the UPBEAT Trial.

• DOI: 10.3390/nu13061979
• 发表时间: 2021-06-09
• 期刊: Nutrients
• 影响因子: 5.9
• 作者: Dalrymple KV;Uwhubetine O;Flynn AC;Pasupathy D;Briley AL;Relph SA;Seed PT;O'Keeffe M;Poston L
• 通讯作者: Poston L

Modifiable early life exposures associated with adiposity and obesity in 3-year old children born to mothers with obesity.

• DOI: 10.1111/ijpo.12801
• 发表时间: 2021-11
• 期刊: Pediatric obesity
• 影响因子: 3.8
• 作者: Dalrymple KV;Flynn AC;Seed PT;Briley AL;O'Keeffe M;Godfrey KM;Poston L;UPBEAT Consortium
• 通讯作者: UPBEAT Consortium

DNA methylation signatures in cord blood associated with birthweight are enriched for dmCpGs previously associated with maternal hypertension or pre-eclampsia, smoking and folic acid intake.

• DOI: 10.1080/15592294.2021.1908706
• 发表时间: 2022-04
• 期刊: Epigenetics
• 影响因子: 3.7
• 作者: Antoun E;Titcombe P;Dalrymple K;Kitaba NT;Barton SJ;Flynn A;Murray R;Garratt ES;Seed PT;White SL;Cooper C;Inskip HM;Hanson M;Poston L;Godfrey KM;Lillycrop KA;UPBEAT Consortium/EpiGen Consortium
• 通讯作者: UPBEAT Consortium/EpiGen Consortium

Longitudinal dietary trajectories from pregnancy to 3 years post delivery in women with obesity: relationships with adiposity.

肥胖女性从怀孕到产后 3 年的纵向饮食轨迹：与肥胖的关系。

• DOI: 10.1002/oby.23706
• 发表时间: 2023
• 期刊: Obesity (Silver Spring, Md.)
• 作者: Dalrymple KV