Rational Design of Plasmonic Nanoassemblies for Rapid and Multiplexed Point-of-Care Diagnosis by Surface-enhanced Raman Spectroscopy (SERS)

通过表面增强拉曼光谱 (SERS) 进行快速、多重现场护理诊断的等离子体纳米组件的合理设计

• 批准号: DE140101056
• 负责人: Prof Yuling Wang
• 金额: $ 26.59万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-06-30 至 2018-11-20
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE140101056
• 关键词: Rational; Design; Plasmonic; Nanoassemblies; Rapid

The central aim of this project is to develop a novel technology/sensor platform for rapid, quantitative, multiplexed and highly sensitive point-of-care diagnostics using surface-enhanced Raman spectroscopy (SERS) as the read-out approach. Three-dimensional plasmonic superstructures as novel SERS labels will be synthesised and characterised at single-particle level and the choice of optimal SERS-active three-dimensional superstructures for use will be guided by empirical structure-activity correlations in combination with computer simulations. Tumour biomarkers for breast cancer will be employed as the model target for establishing the detection platform in a portable configuration for point-of-care diagnostics.

该项目的中心目标是开发一种新型技术/传感器平台，用于快速，定量，多路复用和高灵敏度的床旁诊断，使用表面增强拉曼光谱（Sers）作为读出方法。三维等离子体超结构作为新型Sers标签将在单粒子水平上合成和表征，并且最佳SERS活性三维超结构的选择将由经验结构活性相关性结合计算机模拟来指导。乳腺癌的肿瘤生物标志物将被用作模型目标，用于建立便携式配置的检测平台，用于护理点诊断。