Integrated Nanoplatform for Multiomics Analysis of Cell-to-Cell Interaction

用于细胞间相互作用多组学分析的集成纳米平台

• 批准号: FT210100737
• 负责人: Prof Yuling Wang
• 金额: $ 64.57万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT210100737
• 关键词: Integrated; Nanoplatform; Multiomics; Analysis; Cell

This project aims to develop an integrated nanoplatform for analysis of exosomes produced by host-pathogen interaction at the single cell level. This will be accomplished by engineering an innovative device involving plasmonic nanoparticles to probe exosomes molecular profiles over time. The intended outcome is a generic and robust platform for detailed molecular analysis of the consequences of cell-to-cell interactions. Single cell scale will greatly improve detection accuracy for heterogeneous cell populations. Benefits will include new knowledge of cell-to-cell communication and intellectual property in manufacturing, which will foster collaborations across institutions and Australian industry by providing new technological solutions.

该项目旨在开发一个集成的纳米平台，用于在单细胞水平上分析宿主-病原体相互作用产生的外泌体。这将通过设计一种创新装置来实现，该装置涉及等离子体纳米粒子，以随着时间的推移探测外泌体的分子谱。预期的结果是一个通用且强大的平台，用于对细胞间相互作用的后果进行详细的分子分析。单细胞规模将大大提高异质细胞群的检测准确性。好处将包括细胞间通信和制造知识产权的新知识，这将通过提供新的技术解决方案促进机构和澳大利亚工业之间的合作。