INTRA-ABDOMINAL FAT AND RISK OF DISEASE IN ADOLESCENTS

青少年腹内脂肪与疾病风险

• 批准号: 6181703
• 负责人: Michael Isaac Goran
• 金额: $ 40.61万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2002-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6181703
• 关键词: adipose tissue; adolescence (12-20); bioenergetics; blood chemistry; blood lipid; blood pressure; body composition; body physical activity; carbohydrate metabolism; cardiovascular disorder; clinical research; disease /disorder proneness /risk; epidemiology; gender difference; human subject; insulin; insulin sensitivity /resistance; longitudinal human study; noninsulin dependent diabetes mellitus; obesity; racial /ethnic difference; sex hormones

There are distinct gaps in our understanding of the link between obesity and/or fat distribution and increased disease risk in adolescent children. We propose a 5-year longitudinal study to examine the temporal relationships between changes in body fat, body fat pattern, insulin sensitivity, lipd profile, physical activity, and sex hormones during adolescent growth. We will use state-of-the-art techniques for measuring total body fat (4-compartment model), body fat pattern (dual energy X-ray absorptiometry, computed tomography), physical activity (combination of doubly labeled water and indirect calorimetry), and whole-body insulin sensitivity (Bergman Minimal model). We will examine blood pressure and circulation lipid and lipoprotein levels as risk factors for cardiovascular disease, and fasting indulin and insulin sensitivity as risk factors for non-insulin dependent diabetes mellitus. We propose to study Caucasian and African American adolescents because these groups are at increased risk of obesity and related diseases and have not been thoroughly examined. Preliminary data and recent publications from other investigators support the concept that accumulation of body fat in the intra- abdominal region begins to occur before and during adolescence. Moreover, these data provide evidence that the relationship between obesity and disease risk in adolescents may be explained by accumulation of intra-abdominal adipose tissue (IAAT). Thus, we propose to examine the following hypotheses: 1) The relationship between obesity and disease risk in Caucasian and African American adolescents is due specifically to the accumulation of IAAT; 2) Physical inactivity, total body fat, and sex hormone levels contribute to the development of IAAT during adolescence, which leads to the development of insulin resistance which in turn leads to the development of dyslipidemia. The strength of these cause and effect relationships will not be significantly influenced by ethnicity, or gender; and ,3) IAAT can be accurately predicted from anthropometry, and more accurate equations can be developed by inclusion of total abdominal fat by dual energy X-ray absorptiometry. Our unifying hypothesis is that the development of IAAT during adolescence is the specific cause of increased risk of disease resulting from obesity. This longitudinal study will add to our understanding of the etiology of obesity and the emergence of different body fat patterns during adolescent development. The study will yield substantial information of the mechanism(s) relating obesity to increased disease risk in Caucasian and African American adolescents, and this information will be useful for the design of prevention and intervention programs aimed at reducing long term risk of disease.

我们对这两者之间的联系的理解存在明显的差距。 肥胖和/或脂肪分布与青少年疾病风险增加 孩子 我们建议进行一项为期5年的纵向研究， 体脂肪，体脂肪模式， 胰岛素敏感性、脂蛋白分布、体力活动和性激素 在青少年的成长过程中。 我们将使用最先进的技术 测量全身脂肪（4-房室模型），体脂肪模式 (dual能量X线吸收测定法，计算机断层扫描），物理 活性（双标记水和间接 量热法）和全身胰岛素敏感性（Bergman Minimal 模型）。 我们将检查血压和循环脂质， 脂蛋白水平是心血管疾病的危险因素， 胰岛素敏感性与非胰岛素依赖型糖尿病的危险因素 糖尿病的 我们建议研究高加索人和非洲人 美国青少年，因为这些群体的风险增加， 肥胖和相关疾病，并没有得到彻底的检查。 其他研究者的初步数据和近期出版物 支持的概念，体内脂肪的积累， 腹部区域开始出现之前和青春期期间。 此外，这些数据提供了证据表明， 青少年的肥胖和疾病风险可以解释为 腹腔内脂肪组织（IAAT）。 因此我们 我建议检查以下假设：1）关系 肥胖和疾病风险之间的关系 青少年是由于具体的积累IAAT; 2） 缺乏身体活动、体内脂肪总量和性激素水平 青少年时期IAAT的发展，这导致 胰岛素抵抗的发展，进而导致 血脂异常的发展。 这些因果关系的强度 关系不会受到种族的显著影响，或者 性别;和，3）IAAT可以根据 人体测量，更准确的方程可以开发， 通过双能X线吸收测定法纳入腹部脂肪总量。 我们的统一假设是，IAAT在 青春期是导致疾病风险增加的具体原因， 从肥胖。 这项纵向研究将增加我们对 肥胖症的病因和不同体脂肪的出现 在青少年发展过程中。 这项研究将产生 与肥胖相关的机制的实质性信息， 高加索和非洲裔美国青少年的疾病风险增加， 这些信息将有助于设计预防措施， 旨在降低长期患病风险的干预计划。