The developmental role of metabolism, appetite and growth in eating disorders: exploring novel longitudinal risk pathways

新陈代谢、食欲和生长在饮食失调中的发育作用：探索新的纵向风险途径

• 批准号: MR/R004803/1
• 负责人: Nadia Micali
• 金额: $ 27.45万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FR004803%2F1
• 关键词: developmental; role; metabolism; appetite; growth

The Eating Disorders (full and partial syndrome anorexia nervosa and bulimia nervosa and binge eating disorder) are life-threatening illnesses that start in adolescence and affect between one and two in ten adolescents and young adults. There is a lack in our understanding of why eating disorders develop, which affects our ability to develop good treatments and adequately prevent eating disorders. This project builds on our preliminary data showing that metabolism and growth might play a role in the development of eating disorders; and aims to understand if metabolic function, appetite and growth factors precede onset of eating disorders. We also aim to explore whether these factors might be related to individuals' genetic make up, using novel methodologies and based on novel genetic findings. This study will be based on data from the Avon Study of Parents and Children (ALSPAC), and well-known and unique longitudinal study based in the UK. This study will be fundamental in providing us with an understanding of novel risk mechanisms for adolescent and young adult eating disorders that can be further investigated in larger and more detailed studies following this project.

饮食失调（神经性厌食症、神经性贪食症和暴食症）是一种危及生命的疾病，始于青春期，每10名青少年和年轻人中就有1至2人受到影响。我们对饮食失调产生的原因缺乏理解，这影响了我们开发良好治疗方法和充分预防饮食失调的能力。这个项目建立在我们的初步数据的基础上，这些数据表明新陈代谢和生长可能在饮食失调的发展中发挥作用；目的是了解代谢功能、食欲和生长因子是否先于饮食失调的发生。我们还旨在探索这些因素是否可能与个人的遗传组成有关，使用新的方法和基于新的遗传发现。本研究将基于雅芳父母与儿童研究（ALSPAC）的数据，这是一项著名而独特的英国纵向研究。这项研究将为我们了解青少年和年轻人饮食失调的新风险机制提供基础，可以在该项目之后进行更大规模和更详细的研究。

项目成果

The impact of anorexia nervosa and BMI polygenic risk on childhood growth: A 20-year longitudinal population-based study.

• DOI: 10.1016/j.ajhg.2022.05.005
• 发表时间: 2022-07-07
• 期刊: American journal of human genetics
• 影响因子: 9.8

Eating disorder symptoms and their associations with anthropometric and psychiatric polygenic scores

饮食失调症状及其与人体测量和精神多基因评分的关系

• DOI: 10.1101/2021.06.02.21258214
• 发表时间: 2021
• 作者: Abdulkadir M

The genomics of childhood eating behaviours.

• DOI: 10.1038/s41562-020-01019-y
• 发表时间: 2021-05
• 期刊: Nature human behaviour
• 影响因子: 29.9
• 作者: Herle M;Abdulkadir M;Hübel C;Ferreira DS;Bryant-Waugh R;Loos RJF;Bulik CM;De Stavola B;Micali N
• 通讯作者: Micali N

Eating behavior trajectories in the first 10 years of life and their relationship with BMI.

• DOI: 10.1038/s41366-020-0581-z
• 发表时间: 2020-08
• 期刊: International journal of obesity (2005)
• 作者: Herle M;Stavola B;Hübel C;Ferreira DLS;Abdulkadir M;Yilmaz Z;Loos RJF;Bryant-Waugh R;Bulik CM;Micali N
• 通讯作者: Micali N

Eating disorder symptoms and their associations with anthropometric and psychiatric polygenic scores.

• DOI: 10.1002/erv.2889
• 发表时间: 2022-05
• 期刊: EUROPEAN EATING DISORDERS REVIEW
• 影响因子: 5.3
• 作者: Abdulkadir, Mohamed;Huebel, Christopher;Herle, Moritz;Loos, Ruth J. F.;Breen, Gerome;Bulik, Cynthia M.;Micali, Nadia
• 通讯作者: Micali, Nadia