Biominerals in Health and Disease

生物矿物质在健康和疾病中的作用

• 批准号: MR/R005699/1
• 负责人: Jonathan Powell
• 金额: $ 280.5万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FR005699%2F1
• 关键词: Biominerals; Health; Disease

Almost all biomedical research involves carbon-based (organic) molecules and yet we and other groups have shown that non-carbon based 'mineral' structures have unappreciated roles in supporting normal health and development. Moreover, we have found that by studying these mineral structures and function in biology we have new ideas on how to develop novel mineral-based therapeutics.. Much of our work concentrates on the digestive system and in understanding how our intestinal cells take up mineral structures and with what purpose. Our work integrates different disciplines, such as chemistry, cell biology, human nutrition and immunology, and we collaborate with many different scientists around the world. We then apply some of the lessons learned to other key medical research areas, such as the development of a mineral-based anti-cancer agent. Indeed we are very committed to translating our research findings for nutritional or therapeutic applications that will improve human health. Specifically in this work we will describe:-(a) How and why small mineral particles form naturally in the lumen of the intestine, and what their role is in acting as "cargo ships" that capture fragments of food and bacteria in this environment and then transport the cargo to cells of the intestinal immune system as a part of 'surveillance' for normal human health.(b) Whether in Crohn's disease patients, the pathway described above is operating normally or not. And, if not, whether this may be secondary to the disease process or in fact carries a risk for the disease process to develop in the first place (i.e. cause or effect)?(c) Whether engineered particles, to which we are all exposed via the diet or pills or personal care products, can hijack the pathway described above, lodge in intestinal cells and tip the balance between health and disease (notably Crohn's disease) in genetically susceptible individuals.(d) Whether in fact the engineered particles to which we are exposed, as described in (c) get beyond the intestine and enter our blood circulation and therefore other tissues of the body. And if so, to what extent does this occur in healthy subjects and in those with Crohn's disease.(e) Whether we can build mineral structures that will purposefully stimulate certain cell types for therapeutic benefit in diseases when the immune system needs a boost - such as in cancer.

几乎所有的生物医学研究都涉及碳基（有机）分子，然而我们和其他小组已经表明，非碳基“矿物”结构在支持正常健康和发育方面具有未被认识到的作用。此外，我们发现，通过研究这些矿物结构和生物学功能，我们对如何开发新的矿物治疗方法有了新的想法。我们的大部分工作集中在消化系统和理解我们的肠道细胞是如何吸收矿物质结构的，以及有什么目的。我们的工作整合了不同的学科，如化学、细胞生物学、人类营养学和免疫学，我们与世界各地许多不同的科学家合作。然后，我们将吸取的一些经验教训应用于其他关键的医学研究领域，例如开发基于矿物质的抗癌剂。事实上，我们非常致力于将我们的研究成果转化为营养或治疗应用，以改善人类健康。具体来说，在这项工作中，我们将描述：-(a)小矿物颗粒如何以及为什么在肠腔中自然形成，以及它们在“货船”中的作用，它们在这种环境中捕获食物和细菌的碎片，然后将货物运输到肠道免疫系统的细胞中，作为“监视”正常人体健康的一部分。(b)在克罗恩病患者中，上述通路是否正常运行。如果不是，这是否可能是继发于疾病过程，还是实际上首先就有疾病过程发展的风险（即因果关系）？(c)我们所有人都通过饮食、药片或个人护理产品接触到的工程颗粒，是否可以劫持上述途径，进入肠道细胞，并在基因易感个体中打破健康与疾病（尤其是克罗恩病）之间的平衡。（四）我们所接触到的工程颗粒，如（三）所述，是否真的越过肠道，进入我们的血液循环，从而进入身体的其他组织。如果是这样，这种情况在健康受试者和克罗恩病患者中发生的程度是多少？(e)我们是否可以建立矿物质结构，在需要增强免疫系统的疾病（例如癌症）时，有目的地刺激某些类型的细胞，以获得治疗效果。

项目成果

Ligand-Doped Copper Oxo-hydroxide Nanoparticles are Effective Antimicrobials.

• DOI: 10.1186/s11671-018-2520-7
• 发表时间: 2018-04-19
• 期刊: Nanoscale research letters
• 作者: Bastos CAP;Faria N;Ivask A;Bondarenko OM;Kahru A;Powell J
• 通讯作者: Powell J

Copper nanoparticles have negligible direct antibacterial impact

• DOI: 10.1016/j.impact.2019.100192
• 发表时间: 2020-01-01
• 期刊: NANOIMPACT
• 影响因子: 4.9
• 作者: Bastos, Carlos A. P.;Faria, Nuno;Powell, Jonathan J.
• 通讯作者: Powell, Jonathan J.

Robust rapid-setting antibacterial liquid bandages

坚固快速凝固抗菌液体绷带

• DOI: 10.17863/cam.75523
• 发表时间: 2020
• 作者: Bastos C

Physiological silicon incorporation into bone mineral requires orthosilicic acid metabolism to SiO44.

生理性硅掺入骨矿物质需要原硅酸代谢为 SiO44。

• DOI: 10.17863/cam.52555
• 发表时间: 2020
• 作者: Chappell H