CHRONOBIOLOGY OF PARTIAL EPILEPSY

部分性癫痫的时间生物学

• 批准号: 2891460
• 负责人: MARK S QUIGG
• 金额: $ 9.71万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2891460
• 关键词: biological clocks; circadian rhythms; disease /disorder model; electroencephalography; kindling; laboratory rat; limbic system; partial seizure; photostimulus; sleep

Mesial temporal lobe epilepsy (MTLE), the most common form of partial epilepsy, affects the majority of patients with uncontrolled seizures. Seizures do not strike randomly but occur in daily patterns. Studies have shown that seizures can cluster at sleep-wake transitions or occur in diurnal or nocturnal patterns. Possible influences on the timing of seizures include the sleep-wake state, exogenous cycles such as the light- dark cycle, or endogenous rhythms of the biological clock. Because of the difficulty in testing these influences in humans, possible mechanisms have not been compared under rigorous conditions. The distinctions among these cycles is important because of their different physiology and potential effects on the timing of seizures. Understanding the temporal influences on seizure occurrences is a critical step in determining the factors that permit expression of seizures. This proposal examines the temporal distribution of spontaneous, limbic seizures in an animal model of partial epilepsy that shares clinical, electrographic, and histological similarities with human MTLE. Preliminary results show that limbic seizures occur non-randomly in a daily rhythm similar to that found in MTLE. In this study we will examine the role of endogenous circadian rhythms, measured by markers of motor activity and body temperature, on seizure timing. We will test these hypothesis. 1) Limbic seizures and the epileptic state alter circadian rhythms. 2) The distribution of limbic seizures is tied to phases of the sleep-wake state. 3) Limbic seizure occurrence is influenced occurrence is influenced by endogenous, circadian rhythms. In summary, the results will determine the chronobiological factors that facilitate partial seizure expression and may provide new perspectives into treatments for poorly controlled epilepsy.

内侧颞叶癫痫（MTLE），最常见的形式部分 癫痫，影响大多数不受控制的癫痫发作患者。 癫痫发作不是随机发生的，而是每天发生的。研究 显示癫痫发作可以在睡眠-觉醒过渡时聚集， 昼夜模式。可能影响的时间 癫痫发作包括睡眠-觉醒状态，外源性周期，如光- 暗周期或生物钟的内源性节律。因为 在人类中测试这些影响的困难，可能的机制 没有在严格的条件下进行比较。这些之间的区别 周期是重要的，因为他们不同的生理和潜力 对癫痫发作时间的影响。理解时间的影响 是确定癫痫发生因素的关键步骤， 允许表达癫痫发作。本提案审查了时间 部分性癫痫动物模型中自发性边缘系统癫痫发作的分布 癫痫的临床、电图和组织学特征 与人类MTLE相似。初步结果显示边缘系统 癫痫发作非随机地以类似于 MTLE。在这项研究中，我们将探讨内源性昼夜节律的作用， 节律，通过运动活动和体温的标记测量， 癫痫发作时间我们将检验这些假设。 1)边缘癫痫发作和癫痫状态改变昼夜节律。 2)边缘系统癫痫发作的分布与睡眠-觉醒的阶段有关 状态 3)边缘癫痫发作的发生受 内源性昼夜节律。 总之，这些结果将确定时间生物学因素， 促进部分癫痫发作表达， 治疗控制不佳的癫痫