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Chronobiology of partial epilepsy

部分性癫痫的时间生物学

基本信息

批准号：
6539482
负责人：
MARK S QUIGG
金额：
$ 12.78万
依托单位：
UNIVERSITY OF VIRGINIA
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-09-30 至 2004-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6539482
关键词：
biological clocks circadian rhythms disease /disorder model electroencephalography kindling laboratory rat limbic system partial seizure photostimulus relapse /recurrence sleep temporal lobe /cortex disorder wakefulness

项目摘要

DESCRIPTION (provided by applicant): Mesial temporal lobe epilepsy (MTLE), the most common partial epilepsy, accounts for the majority of patients with uncontrolled seizures. Seizures in MTLE do not strike randomly but occur in daily patterns. Possible influences on the timing of seizures include those factors that underlie circadian oscillation and that facilitate or inhibit seizures. Influences provided by the hypothalamicpituitaryadrenal axis (HPAA) are logical candidates to modulate seizures and will be the focus of the proposed experiments. This proposal examines the temporal distribution of spontaneous, limbic seizures in a unique animal model of partial epileps~ that shares clinical, electrographic, histological, and timing similarities with MTLE. The specific aim of this proposal is to evaluate the role of endogenous rhythmicity of the HPAA in the circadian modulation of experimental limbic epilepsy. Hypothesis 1. Rhythmicity of the HPAA is intact in experimental epilepsy. Hypothesis 2. Corticosterone releasing hormone (CRH) is differentially affected within the hypothalamus and limbic system by lesions at different levels of the clockHPAA system. Our data suggests that circadian mechanisms continue to function in the epileptic rat and that neuronal density in regions important in HPAA regulation is normal. We will evaluate whether CRH expression remains rhythmic in intact animals as well as in animals that have lesions of the clock or of the HPAA. Hypothesis 3. The normal variations of CRH and corticosterone are necessary for circadian recurrence of limbic seizures. We predict that alterations of inputs into the HPAA will cause changes in the circadian distribution of seizures. Previous results show that seizures occur in an endogenously mediated circadian rhythm.. In summary, these studies will provide insight into the chronoblological factors that facilitate partial seizure expression and may provide new perspectives into treatments for poorly controlled partial epilepsy.

描述（由申请人提供）：内侧颞叶癫痫（MTLE），最常见的部分性癫痫，占大部分患者不受控制的癫痫发作。 MTLE 中的癫痫发作并非随机发生，而是发生在日常模式。对癫痫发作时间的可能影响包括：造成昼夜节律振荡并促进或抑制的因素癫痫发作。下丘脑垂体肾上腺轴 (HPAA) 提供的影响是调节癫痫发作的合乎逻辑的候选者，并将成为重点提出的实验。该提案检查了时间分布在独特的部分性癫痫动物模型中出现自发性边缘癫痫发作〜与以下疾病具有临床、电图、组织学和时间上的相似性 MTLE。该提案的具体目的是评估内源性的作用 HPAA 在实验边缘系统昼夜节律调节中的节律性癫痫。假设 1：实验性癫痫中 HPAA 的节律性是完整的。假设 2. 皮质酮释放激素 (CRH) 受到不同程度的影响下丘脑和边缘系统内不同水平的病变时钟HPAA系统。我们的数据表明昼夜节律机制继续癫痫大鼠的功能以及重要区域的神经元密度 HPAA 调节正常。我们将评估CRH表达是否仍然存在在完整的动物以及有时钟损伤的动物中都有节律或 HPAA 的。假设 3. CRH 和皮质酮的正常变化对于边缘系统癫痫发作的昼夜复发。我们预测输入的改变进入 HPAA 会引起癫痫发作昼夜分布的变化。先前的结果表明，癫痫发作在内源性介导的昼夜节律中发生节奏..总而言之，这些研究将提供对促进部分性发作表达的时间因素，并可能为控制不良的部分疾病的治疗提供新的视角癫痫。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Interictal and postictal circadian and ultradian luteinizing hormone secretion in men with temporal lobe epilepsy.

颞叶癫痫男性发作间期和发作后的昼夜节律和超昼夜黄体生成素分泌。

DOI：
10.1111/j.1528-1167.2006.00617.x
发表时间：
2006
期刊：
Epilepsia
影响因子：
5.6
作者：
Quigg,Mark;Kiely,JamesM;Johnson,MichaelL;Straume,Martin;Bertram,EdwardH;Evans,WilliamS
通讯作者：
Evans,WilliamS

Stroboscopic artifact in digital video-EEG.

数字视频脑电图中的频闪伪影。