Chronobiology of partial epilepsy
Chronobiology of partial epilepsy
批准号:
6539482
负责人:
MARK S QUIGG
金额:
$12.78万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-09-30 至 2004-05-31
中文摘要
描述(由申请人提供):内侧颞叶癫痫(MTLE),
最常见的部分性癫痫,占大多数患者,
无法控制的癫痫MTLE中的癫痫发作不是随机发生的,
日常模式对癫痫发作时间的可能影响包括
昼夜节律振荡的基础因素,促进或抑制
癫痫发作下丘脑-垂体-肾上腺轴(HPAA)的影响
是调节癫痫发作的合理候选者,将成为
提出的实验。本提案审查了
在一个独特的部分性癫痫动物模型中,
与具有临床、电图、组织学和时间相似性
MTLE。本建议的具体目的是评估内生性的作用,
HPAA在实验性边缘系统昼夜节律调节中的节律性
癫痫
假设1. HPAA的节律性在实验性癫痫中是完整的。
假设2.皮质酮释放激素(CRH)受到不同程度的影响,
在下丘脑和边缘系统的病变,在不同水平的
clockHPAA系统。我们的数据表明,昼夜节律机制继续
在癫痫大鼠的功能和神经元密度的重要区域,
HPAA调节正常。我们将评估CRH表达是否仍然存在,
在完整的动物以及有生物钟损伤的动物中,
或HPAA。
假设3. CRH和皮质酮的正常变化是必要的,
边缘癫痫的昼夜节律复发我们预测,
将导致癫痫发作的昼夜分布发生变化。
先前的研究结果表明,癫痫发作发生在一个内源性介导的昼夜节律
节奏..总之,这些研究将提供深入了解
促进部分癫痫发作表达的时间因素,
为治疗控制不良的部分
癫痫
英文摘要
DESCRIPTION (provided by applicant): Mesial temporal lobe epilepsy (MTLE), the
most common partial epilepsy, accounts for the majority of patients with
uncontrolled seizures. Seizures in MTLE do not strike randomly but occur in
daily patterns. Possible influences on the timing of seizures include those
factors that underlie circadian oscillation and that facilitate or inhibit
seizures. Influences provided by the hypothalamicpituitaryadrenal axis (HPAA)
are logical candidates to modulate seizures and will be the focus of the
proposed experiments. This proposal examines the temporal distribution of
spontaneous, limbic seizures in a unique animal model of partial epileps~ that
shares clinical, electrographic, histological, and timing similarities with
MTLE. The specific aim of this proposal is to evaluate the role of endogenous
rhythmicity of the HPAA in the circadian modulation of experimental limbic
epilepsy.
Hypothesis 1. Rhythmicity of the HPAA is intact in experimental epilepsy.
Hypothesis 2. Corticosterone releasing hormone (CRH) is differentially affected
within the hypothalamus and limbic system by lesions at different levels of the
clockHPAA system. Our data suggests that circadian mechanisms continue to
function in the epileptic rat and that neuronal density in regions important in
HPAA regulation is normal. We will evaluate whether CRH expression remains
rhythmic in intact animals as well as in animals that have lesions of the clock
or of the HPAA.
Hypothesis 3. The normal variations of CRH and corticosterone are necessary for
circadian recurrence of limbic seizures. We predict that alterations of inputs
into the HPAA will cause changes in the circadian distribution of seizures.
Previous results show that seizures occur in an endogenously mediated circadian
rhythm.. In summary, these studies will provide insight into the
chronoblological factors that facilitate partial seizure expression and may
provide new perspectives into treatments for poorly controlled partial
epilepsy.
期刊论文(7)
专著(0)
科研奖励(0)
会议论文
Interictal and postictal circadian and ultradian luteinizing hormone secretion in men with temporal lobe epilepsy.
颞叶癫痫男性发作间期和发作后的昼夜节律和超昼夜黄体生成素分泌。
DOI:
10.1111/j.1528-1167.2006.00617.x
发表时间:
2006
期刊:
Epilepsia
影响因子:
5.6
作者:
[Quigg,Mark, Kiely,JamesM, Johnson,MichaelL, Straume,Martin, Bertram,EdwardH, Evans,WilliamS]
通讯作者:
Evans,WilliamS
Stroboscopic artifact in digital video-EEG.
数字视频脑电图中的频闪伪影。
DOI:
10.1097/00004691-200403000-00003
发表时间:
2004
期刊:
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society
影响因子:
--
作者:
[Quigg,Mark, Taft,William]
通讯作者:
Taft,William
Clinical Research Site for the Network of Excellence in Neuroscience Clinical Trials (NeuroNEXT)
-
批准号:10593629
-
项目类别:
-
资助金额:$32.3万
-
财政年份:2018
-
负责人:MARK S QUIGG
-
依托单位:
Clinical Research Site for the Network of Excellence in Neuroscience Clinical Trials (NeuroNEXT)
-
批准号:9975920
-
项目类别:
-
资助金额:$32.3万
-
财政年份:2018
-
负责人:MARK S QUIGG
-
依托单位:
Clinical Research Site for the Network of Excellence in Neuroscience Clinical Trials (NeuroNEXT)
-
批准号:10201769
-
项目类别:
-
资助金额:$32.3万
-
财政年份:2018
-
负责人:MARK S QUIGG
-
依托单位:
PATHOPHYSIOLOGICAL BASIS OF LUTEINIZING HORMONE SECRETION PATTERNS IN EPILEPSY
-
批准号:7205501
-
项目类别:
-
资助金额:$3.7万
-
财政年份:2005
-
负责人:MARK S QUIGG
-
依托单位:
CHRONOBIOLOGY OF PARTIAL EPILEPSY
-
批准号:2796982
-
项目类别:
-
资助金额:$9.71万
-
财政年份:1997
-
负责人:MARK S QUIGG
-
依托单位:
CHRONOBIOLOGY OF PARTIAL EPILEPSY
-
批准号:2454944
-
项目类别:
-
资助金额:$7.67万
-
财政年份:1997
-
负责人:MARK S QUIGG
-
依托单位:
CHRONOBIOLOGY OF PARTIAL EPILEPSY
-
批准号:2891460
-
项目类别:
-
资助金额:$9.71万
-
财政年份:1997
-
负责人:MARK S QUIGG
-
依托单位:
Chronobiology of partial epilepsy
-
批准号:6341405
-
项目类别:
-
资助金额:$12.78万
-
财政年份:1997
-
负责人:MARK S QUIGG
-
依托单位:
海外基金