NONINVASIVE TEST FOR MANAGEMENT OF NONULCER DYSPEPSIA

描述（改编自研究者摘要）：非溃疡性消化不良是 一种非常普遍的疾病，影响了多达30%的西方国家， 人口，占所有成人初级保健就诊人数的2- 5% 导致价值超过10亿美元的上消化道内窥镜检查 每年的程序。为了减轻这个巨大的负担， 医疗保健系统目前的一般做法是试图避免 内镜检查在大多数患者中，这是在低风险，由最初的 药物的实验性试验内窥镜检查可以在那些 初始治疗失败。不幸的是，经验治疗只有在 大约40- 50%的病例，因为很难提前确定 最有效的治疗。因此，内窥镜检查的高成本继续 是个问题该提案的总体目标是开发一种廉价的， 非侵入性测试，用于客观和定量分类 为非溃疡性消化不良患者提供最有效的 初步治疗。有效的初始治疗是最重要的 限制不必要地使用昂贵的调查程序， 上消化道内窥镜检查 拟定商业应用：不可用

DESCRIPTION (Adapted from the Investigator's Abstract): Non-ulcer dyspepsia is a highly prevalent medical condition affecting up to 30 percent of the Western population, accounting for 2-5 percent of all adult visits to primary care physicians and leads to over one billion dollars worth of upper endoscopy procedures per year. In an attempt to lower this tremendous burden on the health care system the general practice currently is to attempt to avoid endoscopy in the majority of patients, which are at low risk, by an initial empirical trial of medication. Endoscopy can then be performed in those that fail initial therapy. Unfortunately, empirical treatment is only effective in about 40-50 percent of cases since it is difficult to determine in advance the most effective treatment. Consequently, the high cost of endoscopy continues to be a problem. The overall goal of this proposal is to develop an inexpensive, non-invasive test for the objective and quantitative categorization of non-ulcer dyspepsia patients with the purpose of providing the most effective initial treatment. Effective initial treatment is the single most important action to limit the unnecessary use of expensive investigative procedures, such as upper endoscopy. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE