Noninvasive Test For Management Of Nonulcer Dyspepsia

描述（申请人摘要）：非溃疡性消化不良是一种高度流行的 影响西方人口30%的医疗状况， 占所有初级保健医生和负责人就诊的2- 5% 每年价值超过10亿美元的上消化道内窥镜检查。中 试图减轻医疗保健系统的巨大负担， 目前的做法是试图避免内窥镜检查， 患者，这是低风险的，通过初步的经验性试验的药物。 然后可以对那些初始治疗失败的患者进行内窥镜检查。 不幸的是，经验性治疗仅在约40- 50%的患者中有效。 由于很难事先确定最有效的方法， 治疗因此，内窥镜检查的高成本仍然是一个问题。 该项目的总体目标是开发一种廉价，非侵入性的 非溃疡性消化不良客观定量分类试验 为患者提供最有效的初始治疗。 客观患者分类的有效性将通过 关于预测哪些患者将对酸有反应的能力 抑制治疗，并且其将对促动力治疗有反应。

DESCRIPTION (Applicant's abstract): Nonulcer dyspepsia is a highly prevalent medical condition affecting up to 30 percent of the Western population, accounting for 2-5 percent of all visits to primary care physicians and leads to over one billion dollars worth of upper endoscopy procedures per year. In an attempt to lower this tremendous burden on the health care system the general practice currently is to attempt to avoid endoscopy in the majority of patients, which are low risk, by an initial empiric trial of medication. Endoscopy can then be performed on those that fail initial therapy. Unfortunately, empiric treatment is only effective in about 40-50 percent of cases since it is difficult to determine in advance the most effective treatment. Consequently the high cost of endoscopy continues to be a problem. The overall goal of this project is to develop an inexpensive, non-invasive test for the objective and quantitative categorization of nonulcer dyspepsia patients with the purpose of providing the most effective initial treatment. The effectiveness of objective patient categorization will be tested with respect to ability to predict which patients will be responders to acid suppression therapy and which will be responsive to prokinetic treatment.