Cell Collection Device for Colon Cancer Screening

摘要：该项目的长期目标是开发一种简单易用的设备，用于沿结肠长度取样细胞，以筛查结直肠癌。该装置旨在为当前和未来的结直肠癌DNA标记筛查提供细胞样本。该装置的动机是为患者提供一种方便地收集和储存足够的样本进行筛查的方法，避免了目前需要收集和储存整个肠道运动的需要。这一步骤的消除被认为是一个重要的一步，广泛的患者参与筛选方案与DNA标记筛选的巨大潜力。无论筛查方法的质量如何，除非患者高度参与筛查计划，否则不可能对结直肠癌产生最佳影响。项目简介：该项目旨在开发一种可食用胶囊，该胶囊将从胃肠道中提取细胞样本，用于检测结肠癌的标志物。这将为结肠癌筛查提供一种新的方法，可能具有更好的患者接受度和筛查准确性。这可能会导致美国结直肠癌筛查项目的显著改善，从而显著减少结直肠癌造成的不必要死亡率。

DESCRIPTION (provided by applicant): Abstract: The long term goal of this project is to develop a simple to use device for sampling cells along the length of the colon for purposes of screening for colorectal cancer. This device is intended to be used to provide cell samples for use in current and future DNA marker screens for colorectal cancer. The motivation for the device is to provide a means for patients to easily collect and store an adequate sample for screening that avoids the need to collect and store an entire bowel movement, as is currently required. The elimination of this step is believed to be an important step for broad patient participation in screening programs with the great potential of DNA marker screening. Regardless of the quality of the screening methodology, it will not be possible to have an optimal impact upon colorectal cancer unless there is a high level of patient participation in the screening program. Project Narrative: This project is designed to develop an ingestible capsule that will sample cells from the gastrointestinal tract that can be tested for markers for colon cancer. This would provide a novel method for colon cancer screening that may have better patient acceptance and screening accuracy. This could result in a significant improvement in the colorectal cancer screening programs in the United States which could lead to a significant decrease in unnecessary mortality due to colorectal cancer.