INTEGRATED EEG/FMRI ACQUISITION AND ANALYSIS SYSTEM

集成 EEG/FMRI 采集和分析系统

• 批准号: 6152995
• 负责人: K Jeffrey Eriksen
• 金额: $ 10万
• 依托单位: ELECTRICAL GEODESICS, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6152995
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; brain mapping; electrodes; electroencephalography; electronic recording system; evoked potentials; functional magnetic resonance imaging; human subject; image enhancement; phantom model

Functional magnetic resolution imaging (fMRI) is capable of achieving millimeter spatial resolution in measurements of blood oxygenation associated with neural tissue activation in the brain. Electroencephalography (EEG) is capable of achieving submillisecond temporal resolution of the electrical activity. Many studies can now benefit from the synergy of these two techniques, but simultaneous recording is difficult at present. To fill this gap, we propose to design, prototype, and test an integrated system that will make it easy to record EEG in an MRI scanner during fMRI acquisition. To ensure better comparison for studies not requiring simultaneous recording, we will design the system to perform EEG studies as if they were being conducted in the magnet. In Phase I, we will build and test a 16-channel system, using a physical phantom to demonstrate feasibility. In Phase II, we will then construct a complete 256-channel system to include integrated head stabilization, specialized head coils, rapid and painless application of 256 EEG electrodes, ERP/fMRI experimental design and control software, joint EEG/fMRI segmentation and analysis software, and combined EEG/fMRI source-modeling software. The Phase II system will be tested with a dual EEG/fMRI phantom, as well as in human subjects with visual perceptual and attention experiments. PROPOSED COMMERCIAL APPLICATIONS: The proposed system will be attractive to any lab currently running fMRI experiments, or to anyone setting up a new fMRI lab who wants to include high-density EEG recording in the scanner. Its performance will surpass any other MRI-compatible system now on the market. Because of its fMRI/EEG capability and superior performance, the system will especially appeal to researchers in perception, motor control, and cognitive psychology, as well as clinicians evaluating epilepsy and other brain disorders.

功能磁分辨率成像（fMRI）能够在测量与大脑神经组织激活相关的血液氧合时达到毫米的空间分辨率。脑电图（EEG）能够实现亚毫秒级的脑电活动时间分辨率。许多研究现在可以从这两种技术的协同作用中受益，但目前同时记录是困难的。为了填补这一空白，我们建议设计、制作原型并测试一个集成系统，该系统将使在fMRI采集期间在MRI扫描仪中记录脑电图变得容易。为了确保对不需要同时记录的研究进行更好的比较，我们将设计系统来执行脑电图研究，就好像它们是在磁铁中进行的一样。在第一阶段，我们将构建和测试一个16通道系统，使用物理模型来演示可行性。在第二阶段，我们将构建一个完整的256通道系统，包括集成头部稳定、专用头部线圈、256个脑电电极的快速无痛应用、ERP/fMRI实验设计和控制软件、EEG/fMRI联合分割和分析软件、EEG/fMRI联合源建模软件。第二阶段系统将通过双脑电图/功能磁共振成像（fMRI）幻像进行测试，并在人类受试者中进行视觉感知和注意力实验。拟建的商业应用：拟建的系统将吸引任何正在运行功能磁共振实验的实验室，或任何想要在扫描仪中包含高密度脑电图记录的人建立一个新的功能磁共振实验室。其性能将超过目前市场上任何其他核磁共振兼容系统。由于其fMRI/EEG功能和卓越的性能，该系统将特别吸引知觉、运动控制和认知心理学的研究人员，以及评估癫痫和其他脑部疾病的临床医生。