Integrated EEG/fMRI Acquisition and Analysis System

集成脑电图/功能磁共振成像采集和分析系统

• 批准号: 6659104
• 负责人: K Jeffrey Eriksen
• 金额: $ 33.59万
• 依托单位: ELECTRICAL GEODESICS, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6659104
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; brain imaging /visualization /scanning; clinical research; electrodes; electroencephalography; electronic recording system; evoked potentials; functional magnetic resonance imaging; human subject; image enhancement; phantom model

DESCRIPTION (provided by applicant): Functional MRI is capable of achieving millimeter spatial resolution in measurements of blood oxygenation associated with neural tissue activation in the brain, while the EEG is capable of achieving sub-millisecond temporal resolution of the electrical activity. Many studies can now benefit from the synergy of these two techniques, but simultaneous recording is difficult at present. To fill this gap, we propose to design a prototype and test an integrated system that will make it easy to record EEG in an MRI scanner during fMRI acquisition. For studies not requiring simultaneous recording the system will be designed to carry out EEG studies as if they were done in the magnet for better comparison. In Phase I a 32-channel system was built and tested with a physical phantom to demonstrate feasibility. In Phase II a complete 256-channel system will be built to include integrated head stabilization, specialized head-coils, rapid and painless application of 256 EEG electrodes. ERP/fMRI experimental design and control software, joint EEG/fMRI segmentation and analysis software, and combined EEG/fMRI source modeling software. The Phase II system will be tested with a dual EEG/fMRI phantom as well as in human subjects with a visual perceptual experiment.

描述(申请人提供)：功能磁共振成像能够在测量与大脑中神经组织激活相关的血液氧合时达到毫米空间分辨率，而脑电波能够实现电活动的亚毫秒时间分辨率。许多研究现在可以受益于这两种技术的协同作用，但同时记录目前是困难的。为了填补这一空白，我们建议设计一个原型并测试一个集成系统，该系统将使在功能磁共振成像采集期间在MRI扫描仪中记录脑电变得容易。对于不需要同时记录的研究，该系统将被设计为进行EEG研究，就像它们是在磁铁中进行的一样，以便更好地进行比较。在第一阶段，建立了一个32通道系统，并用一个物理模型进行了测试，以证明其可行性。在第二阶段，将建立一个完整的256通道系统，包括集成的头部稳定、专门的头部线圈、256个脑电电极的快速和无痛应用。ERP/fMRI实验设计与控制软件、EEG/fMRI联合分割与分析软件、EEG/fMRI源联合建模软件。第二阶段的系统将用一个双重的脑电/功能磁共振成像模体进行测试，并在人类受试者身上进行视觉感知实验。