STEREOTACTIC EEG SENSOR REGISTRATION

立体定向脑电图传感器注册

• 批准号: 6212317
• 负责人: K Jeffrey Eriksen
• 金额: $ 44.5万
• 依托单位: ELECTRICAL GEODESICS, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-05 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6212317
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; biosensor device; charge coupled device camera; clinical biomedical equipment; clinical research; computer assisted patient care; electroencephalography; epilepsy; human subject; magnetic resonance imaging; nervous system disorder diagnosis; neurosurgery

Accurate sensor location is necessary to properly model the EEG measured from scalp as well as intracranial electrodes. Accurate sensor position knowledge is also required for multimodal registration of functional electrophysiological data with other neuroimaging data including MRI, CT, fMRI, PET, and SPECT. We propose to build a 3D imager with the following features: low cost, fast data acquisition, cross-platform availability, registration with MRI and integration with computer assisted neurosurgery. We will produce a prototype system that will be aimed toward neuroimaging applications. It will calculate the 3D location of scalp sensors using a non-contacting photogrammetric method and capture the head and face surface not obscured by hair. It will use low cost CCD cameras mounted on an open, rigid frame suspended over a subjects head after electrode placement. The controlling computer will rapidly select each camera in turn, digitize and save its image. Special software written will then identify corresponding points in multiple images and compute and display the 3D coordinates of each sensor and selected facial points. This device will enable research and clinical neurophysiologists to easily and rapidly measure electrode positions. It will find special application in the areas of pediatrics, long-term monitoring, and computer assisted neurosurgery. PROPOSED COMMERCIAL APPLICATION: Researchers and clinicians performing realistic modeling and visualization of multielectrode electrophysiology (neuroimaging) and multimodal integration all require a way to measure sensor positions. Our product will be specialized for neurophysiology and will be more cost effective for this area than any other known product available at this time.

准确的传感器定位对于正确模拟从头皮和颅内电极测量的脑电是必要的。功能电生理数据与其他神经成像数据(包括MRI、CT、fMRI、PET和SPECT)的多模式配准也需要准确的传感器位置知识。我们建议建立一个具有以下特点的3D成像仪：低成本、快速数据获取、跨平台可用、MRI注册以及与计算机辅助神经外科的集成。我们将生产一个针对神经成像应用的原型系统。它将使用非接触式摄影测量方法计算头皮传感器的3D位置，并捕捉没有被头发遮挡的头部和面部表面。它将使用低成本的ccd摄像机，安装在电极放置后悬挂在受试者头部上方的开放的刚性框架上。控制计算机将快速依次选择每个摄像头，数字化并保存其图像。然后，编写的特殊软件将在多个图像中识别相应的点，并计算和显示每个传感器和选定的脸部点的3D坐标。该设备将使研究和临床神经生理学家能够轻松、快速地测量电极位置。它将在儿科、长期监护和计算机辅助神经外科等领域得到特殊应用。拟议的商业应用：研究人员和临床医生对多电极电生理(神经成像)和多模式集成进行逼真的建模和可视化，都需要一种测量传感器位置的方法。我们的产品将专门用于神经生理学，在这一领域将比目前可用的任何其他已知产品更具成本效益。