OPTIMIZATION OF TIME-OF-FLIGHT MASS SPECTROSCOPY

提出了一种提高基质辅助激光解吸电离（MALDI）飞行时间质谱（TOF MS）性能的新技术。 这种新方法可以显着扩展线性光谱仪的高分辨率质量范围，因此使TOF更适用于分析复杂的重生物分子混合物。我们的数值计算表明，一个简单的，线性的TOF光谱仪的性能可以提高到更复杂和昂贵的反射系统的水平。 该提案描述了一种新的方法，用于优化线性飞行时间（TOF）光谱仪的性能，而不改变现有的结构。 在第一阶段，我们将使用这种技术来改善TDA研究公司。的电流谱仪，以实验证明这一概念的可行性。拟议的商业应用：该技术将通过使用廉价的附加设备来显著改进TOF质谱仪。 增加的高分辨率质量范围将使TOF-MS成为分析生物分子的更强大的工具。

The development of a new technique to improve the performance of matrix assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry is proposed. This new method could significantly extend the high resolution mass range of linear spectrometers, and would therefore make TOF much more useful for the analysis of complex mixtures of heavy biomolecules. Our numerical calculations show that the performance of a simple, linear TOF spectrometer can be improved to the level of the much more complex and expensive reflection systems. This proposal describes a new approach for optimizing the performance of linear time-of-flight (TOF) spectrometers without alterations to the existing structure. During Phase I we will use this technique to improve TDA Research Inc.'s current spectrometer to experimentally show the feasibility of the concept. PROPOSED COMMERCIAL APPLICATIONS: This technology will offer significant improvements to TOF mass spectrometers through the use of an inexpensive add-on device. The increased high resolution mass range will then make TOF-MS a more powerful tool for the analysis of biomolecules.