GADOLINIUM CONTAINING FULLERENES AS MRI CONTRAST AGENTS

含钆富勒烯作为 MRI 造影剂

• 批准号: 2776395
• 负责人: JOHN M ALFORD
• 金额: $ 37.79万
• 依托单位: TDA RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2776395
• 关键词: bioimaging /biomedical imaging; carbon; chemical synthesis; contrast media; functional magnetic resonance imaging; gadolinium; radiopharmacology; rare earth element; technology /technique development; water solubility

Endohedral fullerenes containing Gd atoms are a promising new class of compounds with the potential to be superior MRI contrast agents. Fullerenes are a newly discovered class of hollow, closed shell, all carbon molecules that can hold single or multiple lanthanide atoms such as gadolinium inside their shell. Such compounds have a number of important advantages as contrast agents in imaging applications. Unlike conventional compounds, the trapped lanthanide is complete protected from the outside environment, and therefore will not be released into the body. In addition, the compounds show very high relaxivities, on the order of five times higher than current imaging agents. As a result, they are ideal in applications where the imaging agent is to be retaining in the body for a long period of time. This project will improve the methods for extracting and purifying the Gd-metallofullerenes, develop improved methods of making the compounds water soluble, and measure the water solubility, relaxivity and stability of the resulting derivitized compounds. The best compounds will be further tested to determine their toxicity, elimination pathways, in vivo distributions and half lives, and their performance in actual MRI imaging experiments. PROPOSED COMMERCIAL APPLICATIONS: This research will lead to the development of an entirely new class of lanthanide fullerene compounds that have potential applications not only in improving contrast in magnetic resonance imaging, but in scintillation imaging, PET imaging and SPECT imaging. This class of compounds could also have applications to the delivery of radio-pharmaceuticals.

含钆原子的内嵌富勒烯是一类很有前途的新型化合物，具有成为上级MRI造影剂的潜力。 富勒烯是一种新发现的中空封闭壳，所有碳分子都可以在壳内容纳单个或多个镧系元素原子，如钆。 这样的化合物作为造影剂在成像应用中具有许多重要的优点。 与传统化合物不同，捕获的镧系元素完全不受外部环境的影响，因此不会释放到体内。 此外，该化合物显示出非常高的弛豫率，比目前的成像剂高五倍。 因此，它们非常适合成像剂在体内长时间保留的应用。该项目将改进提取和纯化Gd-金属富勒烯的方法，开发使化合物溶于水的改进方法，并测量所得衍生化合物的水溶性、弛豫性和稳定性。 最好的化合物将进一步测试，以确定其毒性，消除途径，体内分布和半衰期，以及它们在实际MRI成像实验中的性能。拟议的商业应用：这项研究将导致一类全新的镧系富勒烯化合物的开发，这些化合物不仅在提高磁共振成像的对比度方面具有潜在的应用，而且在闪烁成像，PET成像和SPECT成像中具有潜在的应用。 这类化合物也可以应用于放射性药物的递送。