GADOLINIUM CONTAINING FULLERENES AS MRI CONTRAST AGENTS

含钆富勒烯作为 MRI 造影剂

• 批准号: 6172257
• 负责人: JOHN M ALFORD
• 金额: $ 37.21万
• 依托单位: TDA RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-01 至 2001-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6172257
• 关键词: bioimaging /biomedical imaging; carbon; chemical synthesis; contrast media; functional magnetic resonance imaging; gadolinium; radiopharmacology; rare earth element; technology /technique development; water solubility

Endohedral fullerenes containing Gd atoms are a promising new class of compounds with the potential to be superior MRI contrast agents. Fullerenes are a newly discovered class of hollow, closed shell, all carbon molecules that can hold single or multiple lanthanide atoms such as gadolinium inside their shell. Such compounds have a number of important advantages as contrast agents in imaging applications. Unlike conventional compounds, the trapped lanthanide is complete protected from the outside environment, and therefore will not be released into the body. In addition, the compounds show very high relaxivities, on the order of five times higher than current imaging agents. As a result, they are ideal in applications where the imaging agent is to be retaining in the body for a long period of time. This project will improve the methods for extracting and purifying the Gd-metallofullerenes, develop improved methods of making the compounds water soluble, and measure the water solubility, relaxivity and stability of the resulting derivitized compounds. The best compounds will be further tested to determine their toxicity, elimination pathways, in vivo distributions and half lives, and their performance in actual MRI imaging experiments. PROPOSED COMMERCIAL APPLICATIONS: This research will lead to the development of an entirely new class of lanthanide fullerene compounds that have potential applications not only in improving contrast in magnetic resonance imaging, but in scintillation imaging, PET imaging and SPECT imaging. This class of compounds could also have applications to the delivery of radio-pharmaceuticals.

含有Gd原子的内嵌富勒烯是一类很有前途的新型化合物，有潜力成为优越的MRI造影剂。富勒烯是一种新发现的中空、封闭壳的碳分子，它们的壳内可以容纳单个或多个镧系元素原子，比如钆。这类化合物在成像应用中作为造影剂有许多重要的优点。与传统化合物不同，被捕获的镧系元素完全不受外界环境的影响，因此不会释放到体内。此外，该化合物显示出非常高的弛豫率，比目前的显像剂高五倍。因此，它们在显像剂需要长时间保留在体内的应用中是理想的。本项目将改进gd -金属富勒烯的提取和纯化方法，开发改进的化合物水溶性方法，并测量所得衍生物的水溶性、弛豫性和稳定性。最佳化合物将进一步测试以确定其毒性，消除途径，体内分布和半衰期，以及它们在实际MRI成像实验中的表现。拟议的商业应用：这项研究将导致开发一类全新的镧系富勒烯化合物，它不仅在提高磁共振成像的对比度方面有潜在的应用，而且在闪烁成像、PET成像和SPECT成像方面也有潜在的应用。这类化合物也可以应用于放射性药物的输送。