One Health Drivers of Antibacterial Resistance in Thailand

泰国抗菌素耐药性的健康驱动因素之一

• 批准号: MR/R014922/1
• 负责人: Matthew Avison
• 金额: $ 9.02万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FR014922%2F1
• 关键词: Health; Drivers; Antibacterial; Resistance; Thailand

Like many Overseas Development Assistance (ODA) countries, and particularly those in South and South East Asia, Health and well-being in Thailand is significantly undermined by the high prevalence of antibacterial drug resistance (ABR) in disease-causing bacteria found in humans, animals and the environment. ABR reduces the ability of doctors to treat infections with antibiotics and other antibacterial drugs, with an estimated impact on Thailand in 2010 of38,000 deaths and an economic loss of 1.2 billion US$. ABR rates continue to rise and its impact is rising in parallel.Because of the threat of ABR, the Thai National Strategic Plan on Antimicrobial Resistance (2017-2022) has been instigated. This will involve improved national surveillance for ABR bacteria to quantify the problem, initiatives to reduce the rates of infections and those to reduce the usage of antibiotics and other antibacterial drugs, which are known to select for ABR bacteria. However, even when this strategic plan starts to pay dividends, there will be much still to learn about ABR in Thailand, and in other ODA countries, as is also true for developed countries where ABR reduction strategies have been in place for some time.In this development project, we will build on partnerships we have already initiated between UK and Thai clinicians and academics. We will develop a consortium grant application to address knowledge gaps about ABR in Thailand, which we have identified through discussions between UK and Thai partners. The consortium will consider whether chemicals in the environment - present naturally or as a result of agricultural pollution (e.g. herbicide use) - can select for ABR bacteria. This would render strategies to reduce antibiotic use less effective in reducing ABR in a community where chemical pollution of the environment is common. We will also consider whether ABR bacteria circulate within local environments in rural Thailand, and will measure how this changes over time as the Thai National Strategic Plan on Antimicrobial Resistance progresses. We will perform research aimed at understanding key behaviours around antibiotic use by farmers, farm management practices, and how people make decisions around healthcare. We will use the information that we generate from the microbiology, genomic and chemical screens and the anthropological research to produce mathematical models that can be used to predict useful changes that can be made to reduce ABR in Thailand and other ODA countries. We will also help Thai policymakers evaluate the effectiveness of changes initiated through the Thai National Strategic Plan. Finally, we will develop technologies that will be used to streamline our research; technologies that may also be useful to help local communities tackle the problem of ABR.During the development project we will run a series of workshops in Thailand, which will be used to develop the details of our proposed research project and to identify the study sites we will use. These workshops will also give us the opportunity to share knowledge amongst Thai and UK ABR experts, and bring together a group of early career academics, to raise the knowledge base around ABR in Thailand. We will also discuss postgraduate education strategies, and public engagement events in Thailand. The development phase will also involve a comprehensive investigation of policymaking around ABR in Thailand, enabling us to tailor our consortium research project to the needs and knowledge gaps of these groups and individuals

与许多海外发展援助国家，特别是南亚和东南亚国家一样，泰国的健康和福祉受到人类、动物和环境中发现的致病性细菌中普遍存在的抗菌药物耐药性的严重损害。ABR降低了医生用抗生素和其他抗菌药物治疗感染的能力，据估计，2010年对泰国造成3.8万人死亡和12亿美元的经济损失。ABR利率继续上升，其影响也在同步上升。由于ABR的威胁，泰国已经启动了抗微生物药物耐药性国家战略计划（2017-2022年）。这将涉及改进国家对ABR细菌的监测，以量化问题，减少感染率的举措以及减少抗生素和其他抗菌药物的使用的举措，已知抗生素和其他抗菌药物会选择ABR细菌。然而，即使这一战略计划开始产生效益，泰国和其他官方发展援助国家仍有许多需要了解的地方，减少农业资源的战略已经实施了一段时间的发达国家也是如此。在这个开发项目中，我们将建立在英国和泰国临床医生和学者之间已经建立的伙伴关系的基础上。我们将开发一项财团资助申请，以解决泰国关于ABR的知识差距，这是我们通过英国和泰国合作伙伴之间的讨论确定的。该联盟将考虑环境中的化学物质——自然存在或作为农业污染（例如除草剂的使用）的结果——是否可以选择ABR细菌。这将使减少抗生素使用的策略在减少环境化学污染普遍存在的社区的ABR方面效果不佳。我们还将考虑ABR细菌是否在泰国农村的当地环境中传播，并将衡量随着泰国抗菌素耐药性国家战略计划的进展，这种情况如何随着时间的推移而变化。我们将进行研究，旨在了解农民使用抗生素的关键行为，农场管理实践，以及人们如何围绕医疗保健做出决定。我们将利用我们从微生物学、基因组学和化学筛选以及人类学研究中获得的信息，建立数学模型，用于预测在泰国和其他官方发展援助国家减少ABR的有用变化。我们还将帮助泰国决策者评估通过泰国国家战略计划发起的变革的有效性。最后，我们将开发用于简化研究的技术；这些技术也可能对帮助当地社区解决ABR问题有用。在开发项目期间，我们将在泰国举办一系列研讨会，这些研讨会将用于开发我们提议的研究项目的细节，并确定我们将使用的研究地点。这些研讨会也将使我们有机会在泰国和英国的ABR专家之间分享知识，并将一群早期职业学者聚集在一起，以提高泰国ABR的知识库。我们还将讨论泰国的研究生教育战略和公众参与活动。开发阶段还将涉及对泰国ABR政策制定的全面调查，使我们能够根据这些群体和个人的需求和知识差距调整我们的联盟研究项目

项目成果

One Health drivers of antibacterial resistance: Quantifying the relative impacts of human, animal and environmental use and transmission.

• DOI: 10.1016/j.onehlt.2021.100220
• 发表时间: 2021-06
• 期刊: One health (Amsterdam, Netherlands)
• 作者: Booton RD;Meeyai A;Alhusein N;Buller H;Feil E;Lambert H;Mongkolsuk S;Pitchforth E;Reyher KK;Sakcamduang W;Satayavivad J;Singer AC;Sringernyuang L;Thamlikitkul V;Vass L;OH-DART Study Group;Avison MB;Turner KME
• 通讯作者: Turner KME

The Diversity, Resistance Profiles and Plasmid Content of Klebsiella spp. Recovered from Dairy Farms Located around Three Cities in Pakistan.

• DOI: 10.3390/antibiotics12030539
• 发表时间: 2023-03-08
• 期刊: ANTIBIOTICS-BASEL
• 影响因子: 4.8
• 作者: Habib, Samia;Gibbon, Marjorie J. J.;Couto, Natacha;Kakar, Khadija;Habib, Safia;Samad, Abdul;Munir, Asim;Fatima, Fariha;Mohsin, Mashkoor;Feil, Edward J. J.
• 通讯作者: Feil, Edward J. J.