MAGNETOELASTIC SENSORS FOR BIOMEDICAL MONITORING

用于生物医学监测的磁弹性传感器

• 批准号: 6141448
• 负责人: Keat Ghee Ong
• 金额: $ 10万
• 依托单位: SENTECHBIOMED CORPORATION
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6141448
• 关键词: acidity /alkalinity; biomedical equipment development; consumable /disposable biomedical equipment; elasticity; gastric acid; gastrointestinal function; magnetic field; mechanical pressure; monitoring device; telemetry; temperature

This proposal seeks support for the development and application of a new sensor technology that enables remote, in-situ, real-time simultaneous measurement of pressure, temperature, and pH. The sensors are comprised of ribbon-shaped films of magnetostrictive, magnetoelastic amorphous metallic glass. In response to a magnetic field pulse the sensors efficiently translate magnetic energy into elastic energy which, in turn, acts to mechanically deform the sensor. Since the material is magnetostrictive, the mechanical deformation acts to generate time- varying magnetic flux that can be detected through the use of a remotely located pickup coil. This mechanical deformation demonstrates a resonance the frequency of which is dependent upon the inter-facial physics between the medium and the sensor, allowing determination of pressure, temperature, and liquid viscosity. In combination with a mass changing chemically response layer, chemical analyte concentrations can be monitored as well. The sensors have a unit cost of approximately $0.01, allowing them to be used on a disposable basis. Under the auspices of this program the sensor assembly and processing electronics will be extended, miniaturized, and packaged allowing for translation of the technology from laboratory to application. PROPOSED COMMERCIAL APPLICATION: Remote, real-time, in-situ measurement of gastric pH and pressure from a disposable sensor that the patient could simply swallow would be an immense improvement over current technology for monitoring of esophageal symptoms. The remote query nature of the technology would also find great utility for in-situ monitoring of biological chemical analyte concentrations such as glucose.

该提案寻求支持的一种新的传感器技术，使远程，原位，实时同时测量压力，温度和pH值的开发和应用。传感器由磁致伸缩，磁致弹性非晶金属玻璃的带状薄膜。 响应于磁场脉冲，传感器有效地将磁能转化为弹性能，弹性能又用于使传感器机械变形。由于材料是磁致伸缩的，机械变形用于产生时变磁通量，该时变磁通量可以通过使用远程定位的拾取线圈来检测。这种机械变形证明了共振，其频率取决于介质和传感器之间的界面物理特性，从而可以确定压力、温度和液体粘度。结合质量变化化学响应层，也可以监测化学分析物浓度。 传感器的单位成本约为0.01美元，可一次性使用。在该计划的支持下，传感器组件和处理电子器件将被扩展，小型化和包装，从而将该技术从实验室转化为应用。拟定商业应用：从患者可以简单吞咽的一次性传感器远程、实时、原位测量胃pH值和压力将是对当前用于监测食管症状的技术的巨大改进。该技术的远程查询性质还将发现对于诸如葡萄糖的生物化学分析物浓度的原位监测的巨大效用。