Transcutaneous Nanotube Hydrogen Sensor

描述（由申请人提供）：我们建议开发一种基于纳米多孔二氧化钛的室温经皮氢传感器，能够在存在潜在干扰气体分析物的情况下检测0.1ppm氢。我们预计，所得到的传感器将被应用为绷带，并足够便宜，易于使用的一次性基础上。该项目将建立在高性能气体传感器，传感器电子和传感器集成领域的共同研究人员的工作基础上。 第一阶段的具体实现目标是：{1}扩展TiO 2纳米管氢传感器的制造技术，以精确控制孔隙尺寸，进而确定其氢敏感性。{2}将为制造纳米多孔TiO 2和Al 2 O3而建立的阳极化技术扩展到包括SnO 2和WO 3的附加组合物。{3}将材料结构和成分与气体传感特性相关联，建立用于确定潜在干扰气体混合物（包括CO2、O2、硝酸、氨和丙酮）中氢浓度的算法。{4}根据需要，将不同纳米多孔金属氧化物传感器的响应以电子鼻形式相互关联，以消除干扰气体的影响，从而能够在空气中和室温下以低于1 ppm的水平精确地经皮测量氢气。将所需的数据逻辑处理电子鼻算法减少到具有2 cm x 2 cm占地面积的市售数据采集系统芯片（约25美元）。 在第二阶段，与D。宾夕法尼亚州立儿童医院新生儿重症监护室的James Kendig博士说，经皮氢传感器将用于促进新生儿坏死性小肠结肠炎发病的临床确定，这是一种病因不明的毁灭性疾病，可导致早产儿小肠和大肠壁缺血和坏死。

DESCRIPTION (provided by applicant): We propose to develop a room temperature, transcutaneous hydrogen sensor based upon nanoporous-titania capable of 0.1ppm hydrogen detection in the presence of potentially interfering gas analytes. We anticipate that the resulting sensor will be applied as a bandage, and be inexpensive enough to be readily used on a disposable basis. The project will build upon work of the co-investigators in the fields of high performance gas sensors, sensor electronics, and sensor integration. The specific enabling objectives to be pursued under Phase I are: {1} Extend the TiO2-nanotube hydrogen sensor fabrication technique to enable precise control over pore dimensions which in turn determine its hydrogen sensitivity. {2} Extend the anodization technique established for fabricating nanoporous TiO2 and AI203 to additional compositions including SnO2 and WO3. {3} Correlate material structures and composition with gas sensing properties, establishing algorithms for the determination of hydrogen concentration within potentially interfering gas mixtures that include CO2, O2, nitric acid, ammonia and acetone. {4} As needed, cross correlate the response of different nanoporous metal oxide sensors in an e-nose format to eliminate the effect of interfering gases enabling precise transcutaneous measurement of hydrogen, in air and at room temperature, at sub 1 ppm levels. Reduce the needed data logic processing e-nose algorithms to a commercially available data acquisition system chip (about $25) having a 2 cm x 2 cm footprint. During Phase II in collaboration with D. James Kendig of the Neonatal Intensive Care Unit at the Penn State Children's Hospital (Hershey, PA) the transcutaneous hydrogen sensor will be applied to facilitate clinical determination of the onset of neonatal necrotizing enterocolitis, a devastating disease of uncertain etiology which causes ischemia and necrosis of the small and large intestinal walls of preterm infants.