Magnetoelastic Sensors for Biomedical Monitoring

描述（由申请人提供）：本提案寻求对 进一步开发新的传感器技术， 远程查询真实的时间测量的物理和化学参数。在 响应于磁场脉冲，带状磁致弹性传感器 有效地将磁能转换成弹性能， 使传感器变形。由于该材料是磁致伸缩的，因此机械特性 变形的作用是产生可被检测到的时变磁通量 用感应线圈远程控制机械变形表明， 谐振，其频率取决于传感器质量负载。因此 通过将pH敏感聚合物与磁致弹性基底结合， 无线、无源、廉价的pH传感器。在第一阶段， 证明了磁弹性传感器用于远程查询的可行性 pH值的测量独立于背景盐浓度，并减少 传感器监测电子设备到笔记本秤。阶段的主要目标 II包括信号处理能力的进一步扩展， 电子封装的小型化、聚合物成分的优化 以及响应时间，设计和制造胶囊， 放置用于引入食管，并评估传感器 用于体内pH测量时的性能（猪）。 拟定商业应用： 从被动的、廉价的一次性传感器无线体内测量胃pH将是对用于监测需要经鼻导管的食管症状的当前技术的巨大改进。传感器技术的无线、远程查询性质还将发现对于生物化学分析物浓度（诸如葡萄糖）的原位监测的巨大效用。

DESCRIPTION (provided by applicant): This proposal seeks support for the further development of a new sensor technology that enables in-situ or in-vivo remote query real time measurement of physical and chemical parameters. In response to a magnetic field impulse the ribbon-shaped magnetoelastic sensors efficiently convert magnetic energy to elastic energy, which mechanically deforms the sensor. Since the material is magnetostrictive, the mechanical deformation acts to generate a time-varying magnetic flux that can be detected remotely with a pick-up coil. The mechanical deformation demonstrates a resonance the frequency of which is dependent upon sensor mass loading. Hence by combining a pH sensitive polymer with the magnetoelastic substrate a wireless, passive, inexpensive pH sensor is achieved. In Phase I we have demonstrated the feasibility of magnetoelastic sensors for remote query measurement of pH independently of background salt concentration, and reduced the sensor monitoring electronics to a notebook scale. The key goals of Phase II include a further extension in signal processing capability with miniaturization of the electronics package, optimization of polymer composition and response time, design and fabrication of a capsule within which the sensor is placed for introduction into the esophagus, and evaluation of sensor performance when used for in-vivo pH measurements (in pigs). PROPOSED COMMERCIAL APPLICATION: Wireless in-vivo measurement of gastric pH from passive, inexpensive disposable sensors would be a great improvement over current technology for monitoring of esophageal symptoms which require a trans-nasal catheter. The wireless, remote query nature of the sensor technology would also find great utility for in-situ monitoring of biological chemical analyte concentrations such as glucose.