Magnetoelastic Sensors for Biomedical Monitoring

描述(由申请人提供)：本提案寻求对 进一步开发一种新的传感器技术，使之能够在原位或体内 远程查询实时测量的物理化学参数。在……里面 带状磁弹性传感器对磁场脉冲的响应 高效地将磁能转化为弹性能，这将机械地 使传感器变形。由于这种材料是磁致伸缩的，所以机械 变形会产生可检测到的时变磁通量 使用拾取线圈远程控制。机械变形显示出 其频率取决于传感器质量负载的谐振。因此 通过将pH敏感的聚合物与磁弹性衬底相结合 实现了无线、无源、廉价的pH传感器。在第一阶段，我们有 论证了磁弹性传感器用于远程查询的可行性 PH的测量不受本底盐浓度的影响，降低了 该传感器监测电子产品到笔记本电脑的规模。第二阶段的主要目标 II包括信号处理能力的进一步扩展，包括 电子封装小型化，聚合物组成优化 以及响应时间、设计和制造胶囊，在该胶囊内传感器 被放置以引入食道，并评估传感器 用于体内pH测量时的性能(在猪身上)。 建议的商业应用： 使用无源、廉价的一次性传感器在体内无线测量胃的pH值，将是对目前监测食道症状的技术的极大改进，目前的食道症状监测需要经鼻导管。传感器技术的无线、远程查询特性也将在现场监测葡萄糖等生物化学分析物浓度方面发挥巨大作用。

DESCRIPTION (provided by applicant): This proposal seeks support for the further development of a new sensor technology that enables in-situ or in-vivo remote query real time measurement of physical and chemical parameters. In response to a magnetic field impulse the ribbon-shaped magnetoelastic sensors efficiently convert magnetic energy to elastic energy, which mechanically deforms the sensor. Since the material is magnetostrictive, the mechanical deformation acts to generate a time-varying magnetic flux that can be detected remotely with a pick-up coil. The mechanical deformation demonstrates a resonance the frequency of which is dependent upon sensor mass loading. Hence by combining a pH sensitive polymer with the magnetoelastic substrate a wireless, passive, inexpensive pH sensor is achieved. In Phase I we have demonstrated the feasibility of magnetoelastic sensors for remote query measurement of pH independently of background salt concentration, and reduced the sensor monitoring electronics to a notebook scale. The key goals of Phase II include a further extension in signal processing capability with miniaturization of the electronics package, optimization of polymer composition and response time, design and fabrication of a capsule within which the sensor is placed for introduction into the esophagus, and evaluation of sensor performance when used for in-vivo pH measurements (in pigs). PROPOSED COMMERCIAL APPLICATION: Wireless in-vivo measurement of gastric pH from passive, inexpensive disposable sensors would be a great improvement over current technology for monitoring of esophageal symptoms which require a trans-nasal catheter. The wireless, remote query nature of the sensor technology would also find great utility for in-situ monitoring of biological chemical analyte concentrations such as glucose.