Magnetoelastic Sensors for Biomedical Monitoring

用于生物医学监测的磁弹性传感器

• 批准号: 6444900
• 负责人: Keat Ghee Ong
• 金额: $ 38.81万
• 依托单位: SENTECHBIOMED CORPORATION
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6444900
• 关键词: acidity /alkalinity; biomedical equipment development; consumable /disposable biomedical equipment; elasticity; gastric acid; gastrointestinal function; magnetic field; mechanical pressure; miniature biomedical equipment; monitoring device; swine; telemetry; temperature

DESCRIPTION (provided by applicant): This proposal seeks support for the further development of a new sensor technology that enables in-situ or in-vivo remote query real time measurement of physical and chemical parameters. In response to a magnetic field impulse the ribbon-shaped magnetoelastic sensors efficiently convert magnetic energy to elastic energy, which mechanically deforms the sensor. Since the material is magnetostrictive, the mechanical deformation acts to generate a time-varying magnetic flux that can be detected remotely with a pick-up coil. The mechanical deformation demonstrates a resonance the frequency of which is dependent upon sensor mass loading. Hence by combining a pH sensitive polymer with the magnetoelastic substrate a wireless, passive, inexpensive pH sensor is achieved. In Phase I we have demonstrated the feasibility of magnetoelastic sensors for remote query measurement of pH independently of background salt concentration, and reduced the sensor monitoring electronics to a notebook scale. The key goals of Phase II include a further extension in signal processing capability with miniaturization of the electronics package, optimization of polymer composition and response time, design and fabrication of a capsule within which the sensor is placed for introduction into the esophagus, and evaluation of sensor performance when used for in-vivo pH measurements (in pigs). PROPOSED COMMERCIAL APPLICATION: Wireless in-vivo measurement of gastric pH from passive, inexpensive disposable sensors would be a great improvement over current technology for monitoring of esophageal symptoms which require a trans-nasal catheter. The wireless, remote query nature of the sensor technology would also find great utility for in-situ monitoring of biological chemical analyte concentrations such as glucose.

描述（由申请人提供）：本提案寻求对 进一步开发新的传感器技术， 远程查询真实的时间测量的物理和化学参数。在 响应于磁场脉冲，带状磁致弹性传感器 有效地将磁能转换成弹性能， 使传感器变形。由于该材料是磁致伸缩的，因此机械特性 变形的作用是产生可被检测到的时变磁通量 用感应线圈远程控制机械变形表明， 谐振，其频率取决于传感器质量负载。因此 通过将pH敏感聚合物与磁致弹性基底结合， 无线、无源、廉价的pH传感器。在第一阶段， 证明了磁弹性传感器用于远程查询的可行性 pH值的测量独立于背景盐浓度，并减少 传感器监测电子设备到笔记本秤。阶段的主要目标 II包括信号处理能力的进一步扩展， 电子封装的小型化、聚合物成分的优化 以及响应时间，设计和制造胶囊， 放置用于引入食管，并评估传感器 用于体内pH测量时的性能（猪）。 拟定商业应用： 从被动的、廉价的一次性传感器无线体内测量胃pH将是对用于监测需要经鼻导管的食管症状的当前技术的巨大改进。传感器技术的无线、远程查询性质还将发现对于生物化学分析物浓度（诸如葡萄糖）的原位监测的巨大效用。