IMAGING PROBE: LYMPH NODE IDENTIFICATION & LOCALIZATION

成像探头：淋巴结识别

• 批准号: 6141784
• 负责人: Lawrence R MacDonald
• 金额: $ 13.72万
• 依托单位: PHOTON IMAGING, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2000-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6141784
• 关键词: autoradiography; bioimaging /biomedical imaging; biomedical equipment development; biopsy; gamma radiation; imaging /visualization /scanning; lymph nodes; phantom model; photomultiplier; radiation detector; scintillation cameras

The objective of this proposal is the development of a hand-held imaging probe for preoperative and intra operative localization of Sentinel Lymph Nodes (SLNs). The proposed probe design is a small scintillation camera with intrinsic spatial resolution of approximately 1 mm with a 2 cm x 2 cm physical field of view. The function is to image distributions of 140 keV gamma-rays either prior to surgery or during surgery. If capable of identifying the SLN prior to surgery the patient may be spared the surgical procedure of invasive lymph node biopsy. The use of the probe follows Lymphoscintigraphy whereby a radioactive colloid is followed dynamically with a conventional gamma camera to the lymph node basin that serves the diseased tissue. The first node in the basin (the SLN) is a strong indicator of whether the cancer has spread so the aim is to biopsy that node. The imaging probe will be the first device used in the operating room with imaging capabilities for real-time precise and unambiguous localization of the SLN. Among the innovative features of the imaging probe will be several interchangeable collimators that allow the user to rapidly change the field of view, spatial resolution and gamma-ray sensitivity of the probe. This versatility is important for this application as SLNs are of variable size and depth. The probe will also operate in non-imaging mode and meet the performance standards of existing non-imaging probes whose use in this field is growing. An attractive feature of the device developed here is its cost. It will offer imaging capability at the same cost of currently available non-imaging probes. PROPOSED COMMERCIAL APPLICATIONS: This project will result in an imaging probe to greatly facilitate the localization of the Sentinel Lymph Node during the staging of melanoma and breast cancer, among other potential tumor types. The imaging probe offers great advantages over the currently employed non-imaging probes at the same cost. The dynamic field of Sentinel Node Scintigraphy is growing in acceptance and scope. Many hospitals routinely use Lymphoscintigraphy and could enhance the procedure with this probe. The imaging probe developed here, at no extra cost to existing non-imaging probes, will provide physicians with a more functional instrument that can carry the Sentinel Node technique further and faster.

本提案的目的是开发一种手持式成像探头，用于前哨淋巴结（SLN）的术前和术中定位。所提出的探头设计是一种小型闪烁照相机，其固有空间分辨率约为1 mm，物理视场为2 cm x 2 cm。该功能是在手术前或手术期间对140 keV伽马射线的分布进行成像。如果能够在手术前识别前哨淋巴结，患者可以避免侵入性淋巴结活检的外科手术。使用探头后进行放射性胶体造影，其中放射性胶体通过常规伽马照相机动态跟踪到为病变组织服务的淋巴结盆。盆中的第一个淋巴结（SLN）是癌症是否扩散的有力指标，因此目的是对该淋巴结进行活检。成像探头将是手术室中使用的第一个具有成像功能的设备，用于SLN的实时精确和明确定位。成像探头的创新功能之一将是几个可互换的准直器，允许用户快速改变探头的视场、空间分辨率和伽马射线灵敏度。这种多功能性对于这种应用是重要的，因为SLN具有可变的尺寸和深度。该探头还将在非成像模式下运行，并符合现有非成像探头的性能标准，这些探头在该领域的使用正在增长。这里开发的设备的一个吸引人的特点是它的成本。它将以与目前可用的非成像探头相同的成本提供成像能力。拟议的商业应用：该项目将产生一种成像探针，以极大地促进在黑色素瘤和乳腺癌以及其他潜在肿瘤类型的分期期间定位前哨淋巴结。在相同的成本下，成像探头提供了比当前采用的非成像探头更大的优势。前哨淋巴结闪烁成像的动态领域在接受度和范围上都在增长。许多医院常规使用超声造影术，并可以使用该探头增强程序。在这里开发的成像探头，在没有额外的成本，现有的非成像探头，将提供一个更功能的仪器，可以携带哨兵节点技术进一步和更快的医生。