Imaging Probe: Lymph Node Identification & Localization

成像探头：淋巴结识别

• 批准号: 6529867
• 负责人: Lawrence R MacDonald
• 金额: $ 46.33万
• 依托单位: PHOTON IMAGING, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6529867
• 关键词: autoradiography; bioimaging /biomedical imaging; biomedical equipment development; biopsy; clinical research; gamma radiation; human subject; imaging /visualization /scanning; lymph node neoplasm; lymph nodes; neoplasm /cancer classification /staging; nuclear medicine; phantom model; photomultiplier; radiation detector; scintillation cameras

The objectives of the proposal are optimization of the prototype hand- held imaging camera developed in Phase I, including significant performance improvements and addition of automated image analysis techniques, and evaluation of the camera in clinical studies. The function of the camera is to image distributions of a radiolabeled colloid injected into cancer patients to localize the sentinel lymph node (SLN) in the drainage path of the primary tumor. SLN have been implicated in the spread of malignant cells so the pathology of the SLN is indicative of the spread of cancer. The spread of the colloid from injection can take one or many paths and it may remain close to the primary or travel to distant non-intuitive node basins. These ambiguities make SLN localization challenging and only a handful of experienced specialist are highly successful in SLN localization. The imaging probe developed under this project facilitates SLN localization. The probe can be used before and during surgery to trace the path of the colloid and identify the SLN. One innovation added to the device in Phase II will be automatic image analysis techniques that allow the user to rapidly scan over suspected regions and be notified when concentrations of colloid are detected by the camera. In this way the user is alerted to areas that should be imaged. The hand-held camera promises to reduce the mean surgical time to localize SLN, reduce the number of procedures required to obtain proficiency, increase confidence in SLN localization and minimize surgical intervention. Clinical studies will be conducted to evaluate the effectiveness and utility of the imaging device both preoperatively and intraoperatively. Nuclear medicine physicians inexperienced in SLN localization will evaluate use of the imaging probe presurgically, and SLN experienced surgeons will test the device intraoperatively. Feedback provided by the physicians will contribute to the Phase II optimization process. PROPOSED COMMERCIAL APPLICATIONS: This project will result in an imaging probe to greatly facilitate the localization of the Sentinel Lymph Node during the staging of melanoma and breast cancer, among other potential tumor types. The imaging probe offers great advantages over the currently employed non-imaging probes at the same cost. The dynamic field of Sentinel Node Scintigraphy is growing in acceptance and scope. Many hospitals routinely use Lymphoscintigraphy and could enhance the procedure with this probe. The imaging probe developed here, at no extra cost to wasting non- imaging probes, will provide physicians with a more functional instrument that can carry the Sentinel Node technique further and faster.

该提案的目标是优化第一阶段开发的手持式成像相机原型，包括显着的性能改进和自动图像分析技术的添加，以及临床研究中相机的评估。相机的功能是对注射到癌症患者体内的放射性标记胶体的分布进行成像，以定位原发肿瘤引流路径中的前哨淋巴结（SLN）。 SLN 与恶性细胞的扩散有关，因此 SLN 的病理学可指示癌症的扩散。注入后的胶体的扩散可以采取一条或多条路径，并且它可能保持靠近主要节点盆地或传播到遥远的非直观节点盆地。这些模糊性使得 SLN 本地化具有挑战性，并且只有少数经验丰富的专家在 SLN 本地化方面取得了巨大成功。该项目开发的成像探头有助于 SLN 定位。该探针可在手术前和手术期间使用，以追踪胶体路径并识别 SLN。第二阶段设备中添加的一项创新是自动图像分析技术，该技术允许用户快速扫描可疑区域，并在相机检测到胶体浓度时收到通知。以这种方式，用户被警告应该成像的区域。手持式摄像机有望减少定位 SLN 的平均手术时间、减少获得熟练程度所需的手术数量、增加对 SLN 定位的信心并最大限度地减少手术干预。将进行临床研究以评估术前和术中成像设备的有效性和实用性。在 SLN 定位方面缺乏经验的核医学医生将在术前评估成像探头的使用，而经验丰富的 SLN 外科医生将在术中测试该设备。医生提供的反馈将有助于第二阶段的优化过程。拟议的商业应用：该项目将产生一种成像探针，在黑色素瘤和乳腺癌以及其他潜在肿瘤类型的分期过程中极大地促进前哨淋巴结的定位。在相同成本下，成像探头比目前使用的非成像探头具有很大的优势。前哨节点闪烁扫描的动态领域的接受度和范围都在不断扩大。许多医院常规使用淋巴闪烁扫描，并且可以使用该探头增强手术过程。这里开发的成像探头不会浪费非成像探头的额外成本，将为医生提供功能更强大的仪器，可以将前哨节点技术发挥得更远、更快。