SPECT CAMERA FOR FUNCTIONAL MICROIMAGING OF BRAIN

用于大脑功能显微成像的 SPECT 相机

• 批准号: 6074365
• 负责人: Lawrence R MacDonald
• 金额: $ 20万
• 依托单位: PHOTON IMAGING, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-01-04 至 2002-01-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6074365
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; computer simulation; image enhancement; image processing; miniature biomedical equipment; scintillation cameras; single photon emission computed tomography

This application is in response to NIMH Program Announcement PA 99-007 for micro-imaging the brain and other parts of the nervous system. It is also consistent with NIH's recent announcement of animal imaging as a key new focus. The ultimate goal of the proposed effort is to develop a small, tomographic gamma camera with in vivo imaging capabilities that allow functional quantitative analysis of animal brain images. The proposed camera will be used with recently developed gamma-ray emitting agents most suitable for SPECT to achieve unprecedented spatial and energy resolution through the use of solid-state photodetector technology and innovative geometrical design. The device developed from this proposal will offer researchers the ability to extract far more accurate quantitative information from animal subjects than is currently possible with whole body SPECT systems on the market, or with autoradiographic techniques, which require sacrificing the subject. The proposed camera would be useful to a large number of researchers interested in understanding basic disease processes, and developing tools for diagnosis and therapy. The objective in Phase I will be to construct a detector module with high density readout electronics that allows seamless tiling of many modules into a larger detector unit. The performance goals of the detector are: a module size of approximately 50 mm x 50 mm with a nominal pixel size of 1 mm2, an intrinsic spatial resolution of between 0.5 and 1.5 mm FWHM, and a spectral resolution of 6% to 8% FWHM for 140 keV gamma-rays. The optimal collimation technique(s) for the intended applications shall also be determined during Phase I, and at least one prototype collimator will be fabricated and tested. Tomographic reconstruction algorithms appropriate for this design and application will also be investigated during the first phase of the project. PROPOSED COMMERCIAL APPLICATION: The Phase I and II development will lead to a new generation of SPECT systems expected to combine significant resolution enhancement with lower cost by utilizing new silicon technologies which need only low cost silicon planar processing and allow integration of electronics with the detector. In the third phase we will commercialize dedicated clinical tomographic imagers for microimaging of animals, based on the Phase I and II efforts. There are large commercial market opportunities in the animal imaging area as well and potential for new commercial systems for humans.

此应用程序是为了响应 NIMH 计划公告 PA 99-007，用于对大脑和神经系统其他部分进行显微成像。 这也与 NIH 最近宣布的将动物成像作为新的关键焦点是一致的。该项目的最终目标是开发一种具有活体成像功能的小型断层伽玛相机，可以对动物大脑图像进行功能性定量分析。拟议的相机将与最近开发的最适合 SPECT 的伽马射线发射剂一起使用，通过使用固态光电探测器技术和创新的几何设计来实现前所未有的空间和能量分辨率。根据该提案开发的设备将使研究人员能够从动物受试者中提取比目前市场上的全身 SPECT 系统或需要牺牲受试者的放射自显影技术更准确的定量信息。所提出的相机对于大量有兴趣了解基本疾病过程以及开发诊断和治疗工具的研究人员来说非常有用。第一阶段的目标是构建一个具有高密度读出电子器件的探测器模块，允许将许多模块无缝拼接成更大的探测器单元。探测器的性能目标是：模块尺寸约为 50 mm x 50 mm，标称像素尺寸为 1 mm2，固有空间分辨率在 0.5 至 1.5 mm FWHM 之间，对于 140 keV 伽马射线，光谱分辨率为 6% 至 8% FWHM。还应在第一阶段确定预期应用的最佳准直技术，并且将制造和测试至少一个原型准直器。 适合该设计和应用的断层扫描重建算法也将在项目的第一阶段进行研究。拟议的商业应用：第一阶段和第二阶段的开发将催生新一代 SPECT 系统，预计通过利用新的硅技术，将分辨率显着提高，并降低成本，该技术仅需要低成本的硅平面处理，并允许电子设备与探测器集成。在第三阶段，我们将在第一阶段和第二阶段工作的基础上，将用于动物显微成像的专用临床断层成像仪商业化。动物成像领域也存在巨大的商业市场机会以及人类新商业系统的潜力。