Sub-Millimeter Stimultaneous SPECT-CT for Imaging

用于成像的亚毫米同步 SPECT-CT

• 批准号: 6404785
• 负责人: Lawrence R MacDonald
• 金额: $ 9.35万
• 依托单位: PHOTON IMAGING, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2002-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6404785
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; charge coupled device camera; computer program /software; fiber optics; image enhancement; miniature biomedical equipment; phosphorus; single photon emission computed tomography; tomography

DESCRIPTION (Provided by Applicant): The overall goal of this project is a super-high-resolution simultaneous single photon emission computed tomography (SPECT) and x-ray computed tomography (x-ray CT) system for molecular imaging in small animals. The reconstructed system spatial resolution will be 500-750 um for SPECT and 50-100 um for x-ray CT. The dual modality images will be acquired simultaneously on two separate detectors and automated software will register and fuse the SPECT and CT images so that the features are superimposed. The entire system will be compact enough to mount on a mobile cart so that procedures can be performed in different parts of the laboratory. In Phase I we will work with vendors to develop the scintillates and readout components for the SPECT system in order to achieve the desired spatial resolution. The resulting prototype SPECT camera will be used together with a phosphor coupled to CCD via tapered fiber optic x-ray detector system (to be provided by LORAD) to obtain the first simultaneous SPECT-CT data. The system performance will be evaluated and used as a basis for the Phase II system development. Some software will also be generated to fuse the SPECT and CT images. PROPOSED COMMERCIAL APPLICATION: The Phase I and II development will lead to a new generation of dual-modality imaging systems providing ultra high resolution information about both the anatomy and function of animal subjects under study. There are large emerging markets demanding advancement in techniques and capabilities for studying disease processes in small animals, including genetics research using transgenic and knock-out mouse models, cancer research for both diagnosis and treatment and drug development.

描述（由申请人提供）：本项目的总体目标是 超高分辨率同步单光子发射计算机断层成像 用于分子成像的SPECT和X射线计算机断层扫描（X射线CT）系统 在小动物身上。重建的系统空间分辨率为500-750 对于SPECT为50-100 μ m，对于X射线CT为50-100 μ m。双模态图像将 在两个独立的探测器上同时采集，自动化软件将 配准并融合SPECT和CT图像， 叠加的整个系统将足够紧凑，可以安装在移动的 推车，以便可以在实验室的不同部分执行程序。 在第一阶段，我们将与供应商合作， SPECT系统的组件，以实现所需的空间 分辨率由此产生的原型SPECT相机将与 通过锥形光纤X射线检测器系统耦合到CCD的磷光体（将被 由LORAD提供）以获得第一同步SPECT-CT数据。系统 性能将被评估，并作为第二阶段系统的基础 发展还将生成一些软件来融合SPECT和CT 图像. 拟定商业应用： 第一阶段和第二阶段的发展将导致新一代的双模态成像 提供有关解剖结构和功能的超高分辨率信息的系统 动物实验对象。 有大量的新兴市场需要发展 研究小动物疾病过程的技术和能力，包括 使用转基因和基因敲除小鼠模型的遗传学研究， 诊断和治疗以及药物开发。