TISSUE WATER MEASUREMENTS OF BRAIN EDEMA WITH MRI

描述：(申请者摘要)非常重要的是 能够准确地评估和量化大脑的水肿性状态 这是由不同的病理条件造成的。总体而言, 治疗脑水肿的方法需要对两者都有了解 颅内血容量紊乱的位置和程度 动态平衡。目前缺乏一种敏感、可靠的手段 非侵入性测量大脑水分是一大障碍 脑水肿的有效治疗方法及其相关研究进展 条件。 在这个项目中，我们建议检验一个假设，即三个- 三维磁共振快速成像技术可用于 获取通常受缺血性中风影响的区域的水分含量。 具体地说，我们将测试自旋密度是 准确的方法来估计水分含量。这一假设将是 对不同病理状态的组织水进行检测。这个 与获得准确的自旋密度相关的困难将是 通过使用最先进的成像器的新成像方法进行处理。 选择缺血性脑水肿作为测试范式是因为我们的实验室 有丰富的动物模型方面的经验。 缺血性中风。这个模型的变种表现出不同的模式 有助于检查辨证分型 自旋-晶格驰豫、自旋-自旋驰豫和自旋密度的影响 测量。一项模拟尺寸和尺寸的体模研究 人类大脑的异质性将被用来测试 该方法为今后的临床应用奠定了基础。

DESCRIPTION: (Applicant's Abstract) It is critically important to be able to accurately assess and quantify the edematous state of the brain that results from different pathological conditions. In general, therapeutic approaches to brain edema require an understanding of both the location and magnitude of disturbances in intracranial volume homeostasis. The present lack of a sensitive, reliable means of measuring brain water non-invasively is a major hindrance to the development of effective therapies for cerebral edema and associated conditions. In this project, we propose to test the hypothesis that a three- dimensional magnetic resonance fast imaging technique can be used to obtain water content in regions commonly affected by ischemic stroke. Specifically, we will test the hypothesis that the spin density is an accurate means to estimate the water content. This hypothesis will be tested on different pathological states of the tissue water. the difficulties associated with obtaining accurate spin density will be dealt with by novel imaging methods using a state-of-the-art imager. Ischemic brain edema is chosen as a test paradigm because our laboratory has extensive experience with a well characterized animal model of ischemic stroke. The variants of this model exhibit different patterns of edema formation that lend themselves to examining differential effects on spin-lattice relaxation, spin-spin relaxation and spin density measurements. A phantom study simulating the dimensions and heterogeneity of the human brain will be use to test the feasibility of this proposed method for future clinical applications.