MOTOR CONTROL DEFICITS IN PARKINSONS DISEASE
帕金森病的运动控制缺陷
基本信息
- 批准号:2892255
- 负责人:
- 金额:$ 22.66万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-07-01 至 2001-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (Adapted from Applicant's Abstract): This proposal undertakes
the first systematic motion analyses of the performance of subjects with
Parkinson's Disease (PD) in executing unconstrained, multi-joint 3D reaching
movements. The focus is on uncovering the role that the basal ganglia may
play in integrating sensory information from different sources into the
motor plan. Three-dimensional pointing errors, movement kinematics, and
interjoint coordination will be analyzed. Experiments utilize a
programmable robot arm to present targets in known locations in one of two
planes in space. Subjects will perform movements under a range of
conditions which vary the available sensory information, memory demands, and
task constraints. Spatial Perception Thresholds. Pure perceptual errors
will be measured by having subjects' visually discriminate actual target
locations from nearby locations presented 1-2 sec earlier and then
extinguished. Pointing to Visually Defined Actual and Memorized Targets
With and Without Vision of the Moving Arm. Disturbances in pointing
movements to targets performed in darkened room will be investigated under
different conditions of visual feedback: no visual feedback during the
movement; vision of the moving fingertip but not of the target; vision of
the target but not of the finger; vision of the fingertip and the target.
Pointing to Memorized Targets Defined Proprioceptively. Two modes of
proprioceptive target presentation will be used that will allow or prevent
the subject from having access to central control signals underlying the arm
movement. Pointing to Memorized Targets Defined Cutaneously. Disturbances
in pointing movements to somatosensory targets also will be analyzed and
compared to disturbances for visually or proprioceptively presented targets.
Movement Speed Regulation: Peripheral Deficits versus Central Strategy
Adaptation. Movements to memorize targets performed at different speeds
with and without vision of the arm will be compared. Comparison Across
Patient Groups. Finally, data on Parkinsonian subjects will be compared
with separate data acquired on subjects lacking proprioceptive information
from their limbs as well as subjects with unilateral cortical lesions. This
combination of movement analyses with behavioral manipulations allows
characterization of deficient motor performance and the ability to dissect
out those elements of sensorimotor processing which may be most impaired in
Parkinsonism.
描述(改编自申请人摘要):本提案承诺
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Howard Poizner其他文献
Howard Poizner的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Howard Poizner', 18)}}的其他基金
相似海外基金
The multifarious studies in the function and the dysfunction of human thalamocortical tract - Neurosurgical treatment in cases with intractable functional diseases of the brain (intractable pain and abnormal involuntary movement)
人类丘脑皮质束功能和功能障碍的多方面研究——脑部顽固性功能性疾病(顽固性疼痛和异常不自主运动)的神经外科治疗
- 批准号:
03670671 - 财政年份:1991
- 资助金额:
$ 22.66万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)














{{item.name}}会员




