MOTOR CONTROL DEFICITS IN PARKINSONS DISEASE

描述（改编自申请人摘要）：本提案承担 第一个系统运动分析对象的性能， 帕金森病（PD）在执行无约束，多关节3D达到 动作 重点是揭示基底神经节可能 在将来自不同来源的感官信息整合到 机动车计划。 三维指向误差、运动学和 将分析联合协调。 实验利用了 可编程机器人手臂，以在两个已知位置中的一个中呈现目标， 太空中的飞机 受试者将在一定范围内进行运动， 改变可用的感觉信息、记忆需求和 任务约束。 空间感知控制。 纯知觉错误 将通过让受试者在视觉上区分实际目标来测量 附近位置的位置提前1-2秒显示，然后 熄灭了 指向视觉定义的实际和模拟目标 有视觉和没有视觉的运动手臂。指向干扰 在暗室中进行的向目标的移动将根据 不同条件下的视觉反馈：没有视觉反馈期间， 运动;运动指尖的视觉，但不是目标的视觉; 目标而不是手指;指尖和目标的视觉。 指向主观定义的目标。 两种模式 将使用本体感受性目标呈现， 使受试者不能接触手臂下面的中央控制信号 运动 指向已定义的目标。 扰动 也将分析指向体感目标的运动， 与视觉或本体感知呈现的目标的干扰相比。 运动速度调节：边缘缺陷与中心策略 适应。 以不同速度进行的记忆目标的动作 将比较具有和不具有手臂视觉的情况。 间比较 患者组。 最后，将比较帕金森病患者的数据 在缺乏本体感受信息的受试者上获得单独的数据 从他们的四肢以及受试者与单侧皮质病变。 这 运动分析与行为操纵的结合允许 运动功能和解剖能力缺陷的表征 这些感觉运动处理的元素可能是最受损的， 帕金森症。

DESCRIPTION (Adapted from Applicant's Abstract): This proposal undertakes the first systematic motion analyses of the performance of subjects with Parkinson's Disease (PD) in executing unconstrained, multi-joint 3D reaching movements. The focus is on uncovering the role that the basal ganglia may play in integrating sensory information from different sources into the motor plan. Three-dimensional pointing errors, movement kinematics, and interjoint coordination will be analyzed. Experiments utilize a programmable robot arm to present targets in known locations in one of two planes in space. Subjects will perform movements under a range of conditions which vary the available sensory information, memory demands, and task constraints. Spatial Perception Thresholds. Pure perceptual errors will be measured by having subjects' visually discriminate actual target locations from nearby locations presented 1-2 sec earlier and then extinguished. Pointing to Visually Defined Actual and Memorized Targets With and Without Vision of the Moving Arm. Disturbances in pointing movements to targets performed in darkened room will be investigated under different conditions of visual feedback: no visual feedback during the movement; vision of the moving fingertip but not of the target; vision of the target but not of the finger; vision of the fingertip and the target. Pointing to Memorized Targets Defined Proprioceptively. Two modes of proprioceptive target presentation will be used that will allow or prevent the subject from having access to central control signals underlying the arm movement. Pointing to Memorized Targets Defined Cutaneously. Disturbances in pointing movements to somatosensory targets also will be analyzed and compared to disturbances for visually or proprioceptively presented targets. Movement Speed Regulation: Peripheral Deficits versus Central Strategy Adaptation. Movements to memorize targets performed at different speeds with and without vision of the arm will be compared. Comparison Across Patient Groups. Finally, data on Parkinsonian subjects will be compared with separate data acquired on subjects lacking proprioceptive information from their limbs as well as subjects with unilateral cortical lesions. This combination of movement analyses with behavioral manipulations allows characterization of deficient motor performance and the ability to dissect out those elements of sensorimotor processing which may be most impaired in Parkinsonism.