MOTOR CONTROL DEFICITS IN PARKINSONS DISEASE

帕金森病的运动控制缺陷

• 批准号: 2892255
• 负责人: Howard Poizner
• 金额: $ 22.66万
• 依托单位: RUTGERS THE STATE UNIV OF NJ NEWARK
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2892255
• 关键词: Parkinson's disease; abnormal involuntary movement; clinical research; fingers; human subject; joints; limb movement; memory; neural information processing; neuromuscular system; psychomotor function; sensorimotor system; sensory discrimination; space perception; vision; visual feedback

DESCRIPTION (Adapted from Applicant's Abstract): This proposal undertakes the first systematic motion analyses of the performance of subjects with Parkinson's Disease (PD) in executing unconstrained, multi-joint 3D reaching movements. The focus is on uncovering the role that the basal ganglia may play in integrating sensory information from different sources into the motor plan. Three-dimensional pointing errors, movement kinematics, and interjoint coordination will be analyzed. Experiments utilize a programmable robot arm to present targets in known locations in one of two planes in space. Subjects will perform movements under a range of conditions which vary the available sensory information, memory demands, and task constraints. Spatial Perception Thresholds. Pure perceptual errors will be measured by having subjects' visually discriminate actual target locations from nearby locations presented 1-2 sec earlier and then extinguished. Pointing to Visually Defined Actual and Memorized Targets With and Without Vision of the Moving Arm. Disturbances in pointing movements to targets performed in darkened room will be investigated under different conditions of visual feedback: no visual feedback during the movement; vision of the moving fingertip but not of the target; vision of the target but not of the finger; vision of the fingertip and the target. Pointing to Memorized Targets Defined Proprioceptively. Two modes of proprioceptive target presentation will be used that will allow or prevent the subject from having access to central control signals underlying the arm movement. Pointing to Memorized Targets Defined Cutaneously. Disturbances in pointing movements to somatosensory targets also will be analyzed and compared to disturbances for visually or proprioceptively presented targets. Movement Speed Regulation: Peripheral Deficits versus Central Strategy Adaptation. Movements to memorize targets performed at different speeds with and without vision of the arm will be compared. Comparison Across Patient Groups. Finally, data on Parkinsonian subjects will be compared with separate data acquired on subjects lacking proprioceptive information from their limbs as well as subjects with unilateral cortical lesions. This combination of movement analyses with behavioral manipulations allows characterization of deficient motor performance and the ability to dissect out those elements of sensorimotor processing which may be most impaired in Parkinsonism.

描述(改编自申请者摘要)：本提案承担 首次对受试者的运动表现进行系统的运动分析 帕金森病(PD)在无限制、多关节三维重建中的应用 动静。重点在于揭示基底神经节可能起的作用 在将来自不同来源的感觉信息整合到 机动计划。三维指向误差、运动运动学和 将分析联合间的协调。实验利用了一种 可编程的机器人手臂，可在两个位置中的一个位置显示目标 太空中的飞机。受试者将在以下范围内进行动作 改变可获得的感觉信息、记忆需求和 任务约束。空间知觉阈值。纯粹的知觉错误 将通过让受试者在视觉上区分实际目标来衡量 来自附近位置的位置提前1-2秒出现，然后 熄灭了。指向视觉上定义的实际和记忆的目标 有和没有移动手臂的视觉。指点中的干扰 在暗室中执行的目标移动将根据 视觉反馈的不同条件：过程中没有视觉反馈 移动；移动的指尖的视觉而不是目标的视觉； 目标但不是手指的目标；指尖和目标的视觉。 指着记忆中正确定义的目标。两种模式 将使用本体感受性目标呈现，以允许或阻止 受试者不能访问手臂下面的中央控制信号 有动静。指向刻意定义的记忆目标。骚乱 在指向体感目标的运动中也将分析和 与视觉上或正确地呈现目标的干扰相比。 运动速度调节：外围缺陷与中心策略 适应。记忆以不同速度执行的目标的动作 有视力和没有视力的手臂将被比较。比较范围 病人组。最后，我们将比较帕金森氏症患者的数据 在缺乏本体感觉信息的受试者上获得单独的数据 来自他们的四肢以及患有单侧皮质损伤的受试者。这 将运动分析与行为操作相结合，可以 运动能力和解剖能力低下的特征 排除了感觉运动加工的那些元素，这些元素可能是在 帕金森症。