MOTOR CONTROL DEFICITS IN PARKINSONS DISEASE

帕金森病的运动控制缺陷

• 批准号: 6187906
• 负责人: Howard Poizner
• 金额: $ 23.34万
• 依托单位: RUTGERS THE STATE UNIV OF NJ NEWARK
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6187906
• 关键词: Parkinson's disease; abnormal involuntary movement; clinical research; fingers; human subject; joints; limb movement; memory; neural information processing; neuromuscular system; psychomotor function; sensorimotor system; sensory discrimination; space perception; vision; visual feedback

DESCRIPTION (Adapted from Applicant's Abstract): This proposal undertakes the first systematic motion analyses of the performance of subjects with Parkinson's Disease (PD) in executing unconstrained, multi-joint 3D reaching movements. The focus is on uncovering the role that the basal ganglia may play in integrating sensory information from different sources into the motor plan. Three-dimensional pointing errors, movement kinematics, and interjoint coordination will be analyzed. Experiments utilize a programmable robot arm to present targets in known locations in one of two planes in space. Subjects will perform movements under a range of conditions which vary the available sensory information, memory demands, and task constraints. Spatial Perception Thresholds. Pure perceptual errors will be measured by having subjects' visually discriminate actual target locations from nearby locations presented 1-2 sec earlier and then extinguished. Pointing to Visually Defined Actual and Memorized Targets With and Without Vision of the Moving Arm. Disturbances in pointing movements to targets performed in darkened room will be investigated under different conditions of visual feedback: no visual feedback during the movement; vision of the moving fingertip but not of the target; vision of the target but not of the finger; vision of the fingertip and the target. Pointing to Memorized Targets Defined Proprioceptively. Two modes of proprioceptive target presentation will be used that will allow or prevent the subject from having access to central control signals underlying the arm movement. Pointing to Memorized Targets Defined Cutaneously. Disturbances in pointing movements to somatosensory targets also will be analyzed and compared to disturbances for visually or proprioceptively presented targets. Movement Speed Regulation: Peripheral Deficits versus Central Strategy Adaptation. Movements to memorize targets performed at different speeds with and without vision of the arm will be compared. Comparison Across Patient Groups. Finally, data on Parkinsonian subjects will be compared with separate data acquired on subjects lacking proprioceptive information from their limbs as well as subjects with unilateral cortical lesions. This combination of movement analyses with behavioral manipulations allows characterization of deficient motor performance and the ability to dissect out those elements of sensorimotor processing which may be most impaired in Parkinsonism.

描述（改编自申请人的摘要）：本提案承诺 首次对受试者的表现进行系统的运动分析 帕金森病 (PD) 执行无约束、多关节 3D 到达 动作。 重点是揭示基底神经节可能的作用 发挥将不同来源的感官信息整合到 电机计划。 三维指向误差、运动运动学和 对关节间的协调性进行分析。 实验利用 可编程机器人手臂可在以下两个之一的已知位置呈现目标 太空中的飞机。 受试者将在一定范围内进行动作 改变可用感官信息、记忆需求和 任务限制。 空间感知阈值。 纯粹的知觉错误 将通过受试者视觉辨别实际目标来测量 附近位置的位置提前 1-2 秒呈现，然后 熄灭了。 指向视觉定义的实际和记忆的目标 有或没有移动臂的视觉。指点障碍 在暗室中进行的目标移动将根据 视觉反馈的不同条件：期间没有视觉反馈 移动;看到移动指尖的视野，但看不到目标；的愿景 目标但不是手指；指尖和目标的视觉。 指向本体定义的记忆目标。 两种模式 将使用本体感觉目标呈现来允许或阻止 受试者可以访问手臂下方的中央控制信号 移动。 指向皮肤定义的记忆目标。 干扰 在指向体感目标的运动中也将被分析和 与视觉或本体感觉呈现的目标的干扰相比。 移动速度调节：外围缺陷与中心策略 适应。 以不同速度执行的记忆目标的动作 将比较有和没有视力的手臂。 比较 患者团体。 最后，将比较帕金森病受试者的数据 在缺乏本体感觉信息的受试者上获得单独的数据 来自他们的四肢以及患有单侧皮质病变的受试者。 这 运动分析与行为操纵的结合允许 运动表现和解剖能力缺陷的表征 找出那些可能在以下情况中受损最严重的感觉运动处理要素 帕金森症。