Motor Control Deficits in Parkinson's Disease

帕金森病的运动控制缺陷

基本信息

  • 批准号:
    7441304
  • 负责人:
  • 金额:
    $ 38.63万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1997
  • 资助国家:
    美国
  • 起止时间:
    1997-07-01 至 2008-06-30
  • 项目状态:
    已结题

项目摘要

Understanding the range of dysfunctions in Parkinson's disease (PD), and the degrees to which they are reversible by pharmacological or electrophysiological treatments, can both increase our understanding of PD therapies and help illuminate critical functions of basal ganglia-cortical circuits in the control of movement. Our previous findings have led us to hypothesize that a major difficulty for patients with Parkinson disease (PD) is in assembling and using new sensorimotor mappings or coordinations. These processes play a major role both in ongoing motor performance and in the acquisition of new skills, and, we are finding, are not normalized with dopamine (DA) replacement therapy. The present proposal presents seven experiments that are designed to confirm and extend our hypothesis and to investigate the degrees to which deep brain stimulation to the subthalamic nucleus (STN DBS) and DA replacement therapy are able to remediate deficits in sensorimotor control, coordination, and learning. To contrast the effects of these therapies in the same patients, we will test PD patients ON versus OFF DA replacement prior to their having surgically implanted electrodes, and again after surgery ON and OFF deep brain stimulation (and off medications). The first 4 experiments examine the integration of visual and proprioceptive information, which may be particularly deficient in PD. Subjects will reach to 3D targets presented either visually or kinesthetically with a robot arm under various conditions of visual feedback. The next experiment introduces the requirement that subjects learn to move within a virtual environment as a prerequisite to establishing the new sensorimotor coordinations necessary for accurate target acquisition. We require subjects to master distortions that create discrepancies between the apparent (virtual) and real (proprioceptively signaled) location of their arms. By dissociating movements from their normal sensory correspondences, we will challenge subjects' abilities to reconfigure their sensorimotor coordinations. The final 2 experiments challenge patients by requiring them to integrate different motor acts into a complex motor sequence and to be able to compensate for a mechanical perturbation during such an action. By examining a full range of behaviors, and requiring coordinated motor acts, utilization of variable sensory information to guide behavior, and the learning new sensorimotor correspondences, we can come to a more systematic assessment of motor control in PD and its benefit by treatment. We feel that the approach we take of using such contemporary technologies as 3D immersive virtual realities and robot-guided 3D reaching in examining the degree to which medical versus surgical therapies can ameliorate dysfunctions in PD is unique.
了解帕金森病(PD)功能障碍的范围及其程度

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Howard Poizner其他文献

Howard Poizner的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Howard Poizner', 18)}}的其他基金

MOTOR CONTROL DEFICITS IN PARKINSONS DISEASE
帕金森病的运动控制缺陷
  • 批准号:
    2892255
  • 财政年份:
    1997
  • 资助金额:
    $ 38.63万
  • 项目类别:
Motor Control Deficits in Parkinson's Disease
帕金森病的运动控制缺陷
  • 批准号:
    7059115
  • 财政年份:
    1997
  • 资助金额:
    $ 38.63万
  • 项目类别:
MOTOR CONTROL DEFICITS IN PARKINSONS DISEASE
帕金森病的运动控制缺陷
  • 批准号:
    2039160
  • 财政年份:
    1997
  • 资助金额:
    $ 38.63万
  • 项目类别:
Motor Control Deficits in Parkinson's Disease
帕金森病的运动控制缺陷
  • 批准号:
    7563312
  • 财政年份:
    1997
  • 资助金额:
    $ 38.63万
  • 项目类别:
Motor Control Deficits in Parkinson's Disease
帕金森病的运动控制缺陷
  • 批准号:
    7467806
  • 财政年份:
    1997
  • 资助金额:
    $ 38.63万
  • 项目类别:
Motor Control Deficits in Parkinson's Disease
帕金森病的运动控制缺陷
  • 批准号:
    8109852
  • 财政年份:
    1997
  • 资助金额:
    $ 38.63万
  • 项目类别:
MOTOR CONTROL DEFICITS IN PARKINSONS DISEASE
帕金森病的运动控制缺陷
  • 批准号:
    2735710
  • 财政年份:
    1997
  • 资助金额:
    $ 38.63万
  • 项目类别:
MOTOR CONTROL DEFICITS IN PARKINSONS DISEASE
帕金森病的运动控制缺陷
  • 批准号:
    6187906
  • 财政年份:
    1997
  • 资助金额:
    $ 38.63万
  • 项目类别:
Motor Control Deficits in Parkinson's Disease
帕金森病的运动控制缺陷
  • 批准号:
    7883235
  • 财政年份:
    1997
  • 资助金额:
    $ 38.63万
  • 项目类别:
Motor Control Deficits in Parkinson's Disease
帕金森病的运动控制缺陷
  • 批准号:
    6774316
  • 财政年份:
    1997
  • 资助金额:
    $ 38.63万
  • 项目类别:

相似海外基金

Deconstructing the roles of basal ganglia and cerebellum-related thalamic inputs to motor cortex during control of dexterous behavior
解构基底神经节和小脑相关丘脑输入在控制灵巧行为过程中对运动皮层的作用
  • 批准号:
    10366236
  • 财政年份:
    2022
  • 资助金额:
    $ 38.63万
  • 项目类别:
Deconstructing the roles of basal ganglia and cerebellum-related thalamic inputs to motor cortex during control of dexterous behavior
解构基底神经节和小脑相关丘脑输入在控制灵巧行为过程中对运动皮层的作用
  • 批准号:
    10546492
  • 财政年份:
    2022
  • 资助金额:
    $ 38.63万
  • 项目类别:
The effects of parkinsonism and deep brain stimulation on basal ganglia-thalamocortical circuitry during sleep-wake behavior
帕金森症和深部脑刺激对睡眠-觉醒行为期间基底节-丘脑皮质回路的影响
  • 批准号:
    10374059
  • 财政年份:
    2019
  • 资助金额:
    $ 38.63万
  • 项目类别:
The effects of parkinsonism and deep brain stimulation on basal ganglia-thalamocortical circuitry during sleep-wake behavior
帕金森症和深部脑刺激对睡眠-觉醒行为期间基底节-丘脑皮质回路的影响
  • 批准号:
    10601010
  • 财政年份:
    2019
  • 资助金额:
    $ 38.63万
  • 项目类别:
Neural basis of direct and indirect pathways in the basal ganglia involved in the control of motor expression and goal-directed behavior.
基底神经节中参与运动表达和目标导向行为控制的直接和间接通路的神经基础。
  • 批准号:
    19K16300
  • 财政年份:
    2019
  • 资助金额:
    $ 38.63万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
The Role of Opponent Basal Ganglia Outputs in Behavior
对手基底神经节输出在行为中的作用
  • 批准号:
    10063566
  • 财政年份:
    2017
  • 资助金额:
    $ 38.63万
  • 项目类别:
The Role of Opponent Basal Ganglia Outputs in Behavior
对手基底神经节输出在行为中的作用
  • 批准号:
    10531242
  • 财政年份:
    2017
  • 资助金额:
    $ 38.63万
  • 项目类别:
The Role of Opponent Basal Ganglia Outputs in Behavior
对手基底神经节输出在行为中的作用
  • 批准号:
    10367065
  • 财政年份:
    2017
  • 资助金额:
    $ 38.63万
  • 项目类别:
Basal Ganglia Activity Timing Underlying Habitual Behavior
习惯行为背后的基底神经节活动时间
  • 批准号:
    1557987
  • 财政年份:
    2016
  • 资助金额:
    $ 38.63万
  • 项目类别:
    Continuing Grant
Basal ganglia circuit mechanisms in cognitive behavior and neuropsychiatric pathology
认知行为和神经精神病理学中的基底神经节回路机制
  • 批准号:
    15H04275
  • 财政年份:
    2015
  • 资助金额:
    $ 38.63万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了