INTEGRATED TRAINING IN REPRODUCTIVE ENDOCRINOLOGY

本项目每年培养2名生殖生物学研究生水平的博士前研究员和4名博士后。学员有望继续在基础科学或临床部门从事学术研究工作。15年来，培养了74名博士后（医学博士48人、博士/博士8人、博士/博士18人）和22名研究生。在向生殖内分泌学中心提出正式申请后，由一个由五名成员组成的指导委员会选出受训者，如果是博士预科学生，则向生物医学科学研究生课程提出正式申请。研究生将攻读生物医学博士学位的课程。招收相关学科博士研究生，同时招收妇产科、儿科学、内科等专业博士研究生。所有进入的研究员将由一个指导小组指导，以确定适当的课程，并发起和跟踪研究进展。没有受过研究生教育的医学博士研究员将在三年奖学金的第一年参加研究生课程并进行研究。所有学员将参加每周的生殖生物学研讨会计划和研究研讨会，并将学习分子和细胞生殖生物学课程。研究培训将由生殖内分泌中心的16名成员提供，他们在加州大学旧金山分校医学和牙科学院的基础科学和临床部门担任教职。目前的研究项目涉及生殖生物学中的重要问题，包括：性别决定、生殖道发育、卵巢和睾丸生物学、正常和异常生殖功能的内分泌调节以及不育的遗传学。生殖内分泌中心（REC）实验室和办公室由大约13,000平方英尺的健康科学教学和研究大楼的两层组成。此外，还有灵长类动物设施、临床研究单位和转基因屏障设施可供研究。组织学，激素测量，蛋白质分离和测序，分子生物学核心也可用于培训。

The proposed program is designed to furnish training for two graduate level predoctoral and four postdoctoral fellows per year in reproductive biology. Trainees are expected to go on to academic investigative careers in basic science or clinical departments. The training program has been operative for the past 15 years during which time 74 postdoctoral trainees (48 M.D., 8 M.D./Ph.D.,18/Ph.D.) and 22 graduate students have received training. Trainees are selected by a five member Steering Committee following formal application to the Reproductive Endocrinology Center and, in the case of predoctoral students, to the Biomedical Sciences Graduate Program. Graduate students will pursue a course of study leading to the Ph.D. degree in Biomedical Sciences. Postdoctoral training will be offered to Ph.D. candidates in related disciplines, and also to clinically trained scientists with M.D. degrees and prior specialty training in Obstetrics and Gynecology, Pediatrics or Internal Medicine. All entering fellows will be guided by a mentoring team to determine appropriate course work, and to initiate and follow research progress. M.D. fellows with no prior graduate education will spend the first year of a 3 year fellowship attending graduate level courses and performing research. All trainees will participate in the weekly Reproductive Biology Seminar Program and Research Workshop and will take the Molecular and Cellular Reproductive Biology Course. Research training will be provided by the 16 members of the Reproductive Endocrinology Center who hold faculty positions at UCSF School of Medicine and Dentistry in both basic science and clinical departments. Current research programs address important issues in reproductive biology including: sex determination, development of the reproductive tract, biology of the ovary and testes, endocrine regulation of normal and abnormal reproductive function and genetics of infertility. The Reproductive Endocrinology Center (REC) laboratories and offices consist of approximately 13,000 square feet on two floors of the Health Sciences Instruction and Research Building. In addition a primate facility, clinical research unit and transgenic barrier facility are available for studies. Histology, hormone measurement, protein separation and sequencing, and molecular biology cores also are available for training.