Integrated Training in Reproductive Sciences

描述（由申请人提供）：本培训计划的目的是为生殖内分泌医生和其他科学家在基础科学或临床部门从事生殖生物学的职业做好准备。20年来，培养了82名博士后（医学博士53人，博士29人）和27名研究生。该计划是多方面和广泛的基础，整合分子内分泌学，细胞生物学，细胞信号，遗传学和生理学。研究培训将由生殖科学中心（CRS）的15名成员提供，他们在医学院的基础科学和临床部门担任教职。直接负责研究培训的经验丰富的项目教师具有广泛的科学专业知识和兴趣。目前的研究项目涉及生殖生物学的重要问题，包括：类固醇激素受体的作用机制；类固醇和神经类固醇激素生物合成和作用的分子遗传学调控；生殖道发育；GnRH神经元搏动机制；子宫内膜和胎盘功能的调节；男性和女性不育症的遗传学；胎儿肾上腺的生长发育和分化；性别决定;正常与异常生殖功能的内分泌调节。在正式向CRS申请后，由指导委员会选择受训者，如果是博士预科学生，则选择适当的研究生课程。研究生攻读生物医学科学或生物科学专业的博士学位。博士后培养对象为相关学科博士研究生，具有医学博士学位并经过专业培训的临床科学家。除了规定的课程和实验室或临床研究外，受训者还将参加一系列定期安排的课程、研讨会、期刊俱乐部、会议和研讨会，以负责任的方式进行研究。学员将学习设计和执行基础研究项目，分析数据，并为著名的同行评审期刊撰写论文。学员还要准备和提交校外资助申请，为独立的学术生涯做好进一步的准备。该项目的优势包括：1)教师的不同技能和兴趣；2)教师的互动性；3)教师的大量实验室资源；4)加州大学旧金山分校生殖、内分泌学、细胞生物学、遗传学和相关领域的杰出研究环境。

DESCRIPTION (provided by applicant): The objective of this Training Program is to prepare reproductive endocrine physicians and other scientists for careers in reproductive biology in basic science or clinical departments. The training program has been operative for the past 20 years during which time 82 postdoctoral trainees (53 M.D., 29 Ph.D.) and 27 graduate students have received training. The program is multifaceted and broadly based, integrating molecular endocrinology, cell biology, cell signaling, genetics, and physiology. Research training will be provided by the 15 members of the Center for Reproductive Sciences (CRS) who hold faculty positions in the School of Medicine in both basic science and clinical departments. The experienced Program Faculty members who are directly responsible for the research training have a broad range of scientific expertise and interests. Current research programs address important issues in reproductive biology including: mechanism of steroid hormone receptor action; molecular genetics and regulation of steroid and neurosteroid hormone biosynthesis and action; development of the reproductive tract; mechanism of GnRH neuronal pulsatility; regulation of endometrial and placental function; genetics of male and female infertility; fetal adrenal growth, development and differentiation; sex determination; endocrine regulation of normal and abnormal reproductive function. Trainees are selected by a Steering Committee following formal application to the CRS and, in the case of predoctoral students, to an appropriate graduate program. Graduate students pursue a course of study leading to the Ph.D. degree in Biomedical Sciences or Program in Biological Sciences. Postdoctoral training will be offered to Ph.D. candidates in related disciplines, and also to clinically trained scientists with M.D. degrees and prior specialty training. In addition to prescribed course work and laboratory or clinical research, trainees will participate in a series of regularly scheduled courses, seminars, journal clubs, conferences, and seminars on the responsible conduct of research. Trainees learn to design and execute basic research projects, analyze data and write manuscripts for prominent peer-reviewed journals. Trainees also prepare and submit grant applications for extra-mural funding, preparing them further for independent academic careers. The strengths of the program include: 1) diverse skills and interests of the faculty 2) the interactiveness of the faculty 3) the substantial laboratory resources of the faculty 4) the outstanding environment for research in reproduction, endocrinology, cell biology, genetics and related areas at UCSF.