RACIAL DIFFERENCES IN REGIONAL FAT DISTRIBUTION IN WOMEN

心血管疾病、高血压和糖尿病与 脂肪组织增加，特别是内脏脂肪增加 组织. 然而，令人惊讶的是，最近的研究表明， 黑人女性有更多的总脂肪组织，但更少的内脏脂肪 比白色女人更容易被人发现奇怪的是，黑人女性有更高的 肥胖症的发病率和受肥胖相关的健康问题的影响 比白色女性更是如此。 因此，腹部之间的关系 肥胖和健康问题在黑人人口中可能没有那么严重， 在白色人群中也是如此。 这说明还有其他的 根本原因 在绝经后妇女中， 腹部脂肪增加可能与内分泌改变有关。 绝经期雌激素的变化可能直接或间接地改变 脱氢表雄酮（DHEA）、生长激素（GH）或胰岛素样 生长因子-1（IGF-1）浓度。 这些荷尔蒙与 体脂肪增加（57，59）和/或腹部内脏 脂肪组织（10）。 腹部内脏脂肪和这些激素没有 在黑人或老年人中进行了研究。 此外，本发明还提供了一种方法， 雌激素替代疗法（ERT）可能会改变这些 脂肪组织、激素浓度和健康之间的关系 并发症 为了解决NIA研究目标2，目的 这个项目的目的是确定种族差异是否存在于 局部体脂分布与静息激素的关系 浓度（DHEA，GH和IGF-1）。 此外，我们将确定， 血脂谱与体脂分布的关系 取决于种族和雌激素替代状况 60个年龄匹配的 绝经后妇女（30名黑人和30名白色妇女（15名接受ERT，15名未接受ERT 在ERT上））将具有内脏脂肪组织、激素浓度和 测量血脂谱。 这个项目是第一个 试图观察老年黑人女性的内脏脂肪组织， 试图确定差异是否与血脂有关 曲线和静息激素浓度的差异。

Cardiovascular disease, hypertension and diabetes are associated with increased adipose tissue, in particular, an increase in visceral adipose tissue. Surprisingly, however, recent research has reported that young black women have more total adipose tissue, but less visceral adipose tissue than white women. Paradoxically, black women have a higher incidence of obesity and are affected by obesity-related health problems more so than white women. Thus the relationship between abdominal obesity and health problems may not be as strong in the black population as it is in the white population. This would suggest there are other underlying causes. In postmenopausal women, one possible mechanism for the increased abdominal fat could be linked with endocrine changes. Changes in estrogen with menopause may directly or indirectly alter dehydroepiandrosterone (DHEA), growth hormone (GH) or insulin-like growth factor-1 (IGF-1) concentrations. These hormones have been linked with increased body fat (57, 59) and/or increased abdominal visceral adipose tissue (10). Abdominal visceral fat and these hormones have not been studied in either black or older individuals. In addition, estrogen replacement therapy (ERT) can potentially alter these relationships between adipose tissue, hormone concentrations and health complications. To address NIA research objective number 2, the purpose of this project is to determine if racial differences exist in the relationship between regional body fat distribution and resting hormone concentrations (DHEA, GH and IGF-1). Further we will establish if the relationship between the blood lipid profile and body fat distribution is dependent on race and estrogen replacement status. Sixty age-matched postmenopausal women (30 black and 30 white women (15 on ERT and 15 not on ERT)) will have visceral adipose tissue, hormone concentrations and blood lipid profiles measured. This project is one of the first attempts to look at visceral adipose tissue in older black women and attempt to establish if differences are associated with blood lipid profiles and to differences in resting hormone concentrations.