Autonomic Function and Exercise in Type 2 Diabetics

2 型糖尿病患者的自主功能和运动

• 批准号: 6915024
• 负责人: JILL A KANALEY
• 金额: $ 14.48万
• 依托单位: SYRACUSE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6915024
• 关键词: aerobic exercise; autonomic disorder; clinical research; diabetes mellitus therapy; diabetic neuropathy; gender difference; glucose metabolism; human middle age (35-64); human subject; human therapy evaluation; insulin sensitivity /resistance; myocardial ischemia /hypoxia; noninsulin dependent diabetes mellitus; obesity; patient oriented research

DESCRIPTION (provided by applicant): Diabetic autonomic neuropathy is found with a high incidence in individuals with type 2 diabetes. More specifically, cardiac autonomic neuropathy (CAN) is the most common neuropathy found and is associated with an increase in ischemic heart disease and a higher incidence of arrhythmias and sudden death in obese and type 2 diabetic individuals. Nearly half of diabetic patients have CAN and if they do then the 5-yr mortality is substantially increased. Obesity alone compromises autonomic function, but in type 2 diabetics the hyperinsulinemic milieu is also speculated to further alter autonomic function potentially leading to the higher incidence of arrhythmias and sudden death in this population. Exercise and weight loss has been shown to improve CAN in obese individuals, but the reversibility of CAN in the type 2 diabetic individual is unclear. The purpose of this study is to determine if differences exist in CAN between obese non-diabetics and obese type 2 diabetic individuals, and if this response can be altered by 16 wk of aerobic exercise training. In addition we will also establish if gender differences occur with this response to training. We will recruit 40 men and women (40-60 yr) (20 obese/non-diabetics and 20 obese/ type 2 diabetics). Subjects will exercise train 4 days/wk at 65% V02 max. This study will train subjects in a supervised setting for the first month and then subjects will train in a supervised home-based program. Subjects will be monitored at home via phone, email and a website to track their progress. At the initiation and completion of the study, subjects will have their metabolic status (glucose and insulin levels (OGTT), blood lipids, HbA 1c) and autonomic function (heart rate variability-HRV) measured. This project is one of the first to determine if autonomic function can be improved in type 2 diabetics after participating in an exercise program, which is part of the current therapy. Because of the increased mortality in this population, this project will provide insight into whether autonomic dysfunction can be reversed and if gender differences occur in this response.

描述（由申请人提供）：糖尿病自主神经病变在2型糖尿病患者中的发病率很高。更具体地，心脏自主神经病变（CAN）是发现的最常见的神经病变，并且与肥胖和2型糖尿病个体中缺血性心脏病的增加以及心律失常和猝死的较高发生率相关。近一半的糖尿病患者有CAN，如果他们这样做，那么5年死亡率大幅增加。肥胖单独损害自主神经功能，但在2型糖尿病患者中，高胰岛素血症环境也被推测进一步改变自主神经功能，可能导致该人群中心律失常和猝死的发生率较高。运动和减肥已被证明可以改善肥胖个体的CAN，但CAN在2型糖尿病个体中的可逆性尚不清楚。本研究的目的是确定肥胖非糖尿病患者和肥胖2型糖尿病患者之间CAN是否存在差异，以及16周的有氧运动训练是否可以改变这种反应。此外，我们还将确定这种对培训的反应是否存在性别差异。我们将招募40名男性和女性（40-60岁）（20名肥胖/非糖尿病患者和20名肥胖/2型糖尿病患者）。受试者将在65%V02最大值下进行4天/周的运动训练。本研究将在第一个月在监督环境中培训受试者，然后受试者将在监督的家庭计划中培训。受试者将在家中通过电话、电子邮件和网站进行监测，以跟踪他们的进展。在研究开始和完成时，将测量受试者的代谢状态（葡萄糖和胰岛素水平（OGTT）、血脂、HbA 1c）和自主神经功能（心率变异性-HRV）。该项目是第一个确定2型糖尿病患者参加运动计划后自主神经功能是否可以改善的项目之一，这是目前治疗的一部分。由于这一人群的死亡率增加，该项目将提供关于自主神经功能障碍是否可以逆转以及这种反应是否存在性别差异的见解。

项目成果

Regulation of blood flow by aspirin following muscle ischemia.

阿司匹林在肌肉缺血后调节血流。

• 发表时间: 2012
• 期刊: European review for medical and pharmacological sciences
• 影响因子: 3.3
• 作者: Cameron,SJ;Goulopoulou,S;Weil,BR;Kanaley,JA
• 通讯作者: Kanaley,JA

Satiety, but not total PYY, Is increased with continuous and intermittent exercise.

• DOI: 10.1002/oby.20335
• 发表时间: 2013-10
• 期刊: Obesity (Silver Spring, Md.)
• 作者: Holmstrup ME;Fairchild TJ;Keslacy S;Weinstock RS;Kanaley JA
• 通讯作者: Kanaley JA

Cardiovagal modulation and efficacy of aerobic exercise training in obese individuals.

肥胖个体中有氧运动训练的心脏调节和功效。

• DOI: 10.1249/mss.0b013e3182a66411
• 发表时间: 2014-02
• 期刊: Medicine and science in sports and exercise
• 影响因子: 4.1
• 作者: Baynard T;Goulopoulou S;Sosnoff RF;Fernhall B;Kanaley JA
• 通讯作者: Kanaley JA

Effect of an acute bout of aerobic exercise on chemerin levels in obese adults.

• DOI: 10.1016/j.dsx.2015.04.010
• 发表时间: 2016-01
• 期刊: Diabetes & metabolic syndrome
• 作者: Lloyd JW;Evans KA;Zerfass KM;Holmstrup ME;Kanaley JA;Keslacy S
• 通讯作者: Keslacy S

Exercise training improves hemodynamic recovery to isometric exercise in obese men with type 2 diabetes but not in obese women.

• DOI: 10.1016/j.metabol.2012.07.014
• 发表时间: 2012-12
• 期刊: METABOLISM-CLINICAL AND EXPERIMENTAL
• 影响因子: 9.8
• 作者: Kanaley, Jill A.;Goulopoulou, Styliani;Franklin, Ruth;Baynard, Tracy;Carhart, Robert L., Jr.;Weinstock, Ruth S.;Fernhall, Bo
• 通讯作者: Fernhall, Bo