FEMTOSECOND PULSE LASERS FOR BIOLOGY AND MEDICINE

这项研究的长期目标是开发紧凑、坚固和用户友好的飞秒脉冲激光光源，用于生物和医学应用。例子包括多光子显微镜、光学相干断层成像和飞秒角膜手术。这些来源将为生物和生物物理科学的研究人员提供更多获得新技术的机会，同时加强和扩大他们的能力。其主要目标是发展高能光纤激光器和半导体激光器。由于这些领域的最新进展，开发具有超过块状固体激光器能力的短脉冲源是现实的。光纤和半导体提供了完全集成器件的可能性，这将是新的短脉冲技术获得广泛使用所必需的。这项工作的第二个重点将是开发和应用支持多光子显微镜的测量能力。我们的目标是阐明多光子技术背后的光物理。发展新的和/或增强的能力，在从分子到宏观的水平上可视化和影响组织水平，已经对健康产生了明显的好处，预计未来将产生类似或更大的影响。

The long term objective of this research is the development of compact, robust, and user friendly femtosecond-pulse laser sources for applications in biology and medicine. Examples include multi-photon microscopy, optical coherence tomography imaging and femtosecond corneal surgery. Such sources will provide researchers in the biological and biophysical sciences much greater access to new techniques while enhancing and expanding their capabilities. The primary aim is to develop high-energy fiber lasers and semiconductor lasers. As a result of recent advances in these fields, the development of short-pulse sources with capabilities that will exceed those of bulk solid-state lasers is realistic. Fibers and semiconductors offer the possibility of completely integrated devices, which will be required for new short-pulse techniques to attain widespread use. A secondary focus of this work will be the development and application of measurement capabilities in support of multi-photon microscopy. The goal is to clarify the photo physics underlying multi photon techniques. The development of new and/or enhanced capabilities for visualizing and affecting tissue levels at level ranging from molecular to macroscopic has had obvious health benefits and similar or greater impact can be expected in the future.