FEMTOSECOND PULSE LASERS FOR BIOLOGY AND MEDICINE

用于生物学和医学的飞秒脉冲激光器

• 批准号: 6394635
• 负责人: FRANK W WISE
• 金额: $ 18.22万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-08-01 至 2002-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6394635
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; confocal scanning microscopy; fiber optics; lasers; photomicrography; quantum chemistry; semiconduction; solid state

The long term objective of this research is the development of compact, robust, and user friendly femtosecond-pulse laser sources for applications in biology and medicine. Examples include multi-photon microscopy, optical coherence tomography imaging and femtosecond corneal surgery. Such sources will provide researchers in the biological and biophysical sciences much greater access to new techniques while enhancing and expanding their capabilities. The primary aim is to develop high-energy fiber lasers and semiconductor lasers. As a result of recent advances in these fields, the development of short-pulse sources with capabilities that will exceed those of bulk solid-state lasers is realistic. Fibers and semiconductors offer the possibility of completely integrated devices, which will be required for new short-pulse techniques to attain widespread use. A secondary focus of this work will be the development and application of measurement capabilities in support of multi-photon microscopy. The goal is to clarify the photo physics underlying multi photon techniques. The development of new and/or enhanced capabilities for visualizing and affecting tissue levels at level ranging from molecular to macroscopic has had obvious health benefits and similar or greater impact can be expected in the future.

这项研究的长期目标是为生物和医学应用开发紧凑、坚固、用户友好的飞秒脉冲激光源。例子包括多光子显微镜、光学相干断层成像和飞秒角膜手术。这些资源将为生物和生物物理科学领域的研究人员提供更多获得新技术的机会，同时增强和扩大他们的能力。主要目标是发展高能光纤激光器和半导体激光器。由于这些领域的最新进展，开发短脉冲源的能力将超过大块固体激光器的能力是现实的。光纤和半导体提供了完全集成器件的可能性，这将是新短脉冲技术获得广泛应用所必需的。这项工作的第二个重点将是支持多光子显微镜的测量能力的发展和应用。目的是阐明多光子技术背后的光物理原理。在从分子到宏观水平上可视化和影响组织水平的新的和/或增强的能力的发展已经具有明显的健康益处，并且可以预期在未来会产生类似或更大的影响。