Femtosecond-Pulse Laser for Biology & Medicine

用于生物学的飞秒脉冲激光器

• 批准号: 6472426
• 负责人: FRANK W WISE
• 金额: $ 30.43万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-08-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6472426
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; confocal scanning microscopy; fiber optics; lasers; miniature biomedical equipment; photomicrography; solid state

Description (provided by applicant): The long-term objective of this research is the development of compact, robust, and userfriendly femtosecond-pulse laser sources for applications in biology and medicine. Examples include multi-photon microscopy, optical coherence tomography imaging, and femtosecond comeal surgery. In the last few years alone, researchers in biology and medicine have demonstrated numerous new applications of femtosecond-pulse lasers. Advanced laser sources must be developed if these are to find acceptance outside specialized research laboratories. Such sources will provide researchers in the biological and biophysical sciences much greater access to new techniques while enhancing and expanding their capabilities. The primary aim is to develop high-energy fiber lasers. As a result of recent advances, the development of short-pulse sources with capabilities that will exceed those of bulk solid-state lasers is realistic. Fibers and semiconductors offer the possibility of completely integrated devices, which will be required for new short-pulse techniques to attain widespread use. A secondary focus of this work will be the development and application of measurement capabilities in support of biological imaging techniques. This will include the assessment of semiconductor nanocrystals as fluorophores in multi-photon microscopy. The development of new and/or enhanced capabilities for visualizing and affecting tissue at levels ranging from molecular to macroscopic has had obvious health benefits and similar or greater impact can be expected in the future.

描述（申请人提供）：本研究的长期目标 是开发紧凑、坚固、用户友好的飞秒脉冲激光器 在生物学和医学中的应用。例子包括多光子 光学相干断层扫描成像和飞秒角膜 手术仅在过去的几年里，生物学和医学的研究人员 展示了飞秒脉冲激光器的许多新应用。先进 如果激光源要得到外界的认可， 专门的研究实验室。这些来源将为研究人员提供 生物和生物物理科学获得新技术的机会大大增加， 加强和扩大他们的能力。 其主要目标是发展高能光纤激光器。由于最近的 发展，短脉冲源的能力，将 超过大块固体激光器的那些是现实的。纤维和半导体 提供了完全集成设备的可能性，这将是必需的 使新的短脉冲技术得到广泛应用。 这项工作的第二个重点是开发和应用 支持生物成像技术的测量能力。这将 包括半导体纳米晶体作为荧光团的评估， 多光子显微镜 开发新的和/或增强的能力， 从分子水平到宏观水平影响组织， 可以预期， 未来

项目成果

Noncollinear generation of optical spatiotemporal solitons and application to ultrafast digital logic.

• DOI: 10.1103/physreve.61.r4722
• 发表时间: 2000-05
• 期刊: Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics
• 作者: X. Liu;K. Beckwitt;F. Wise

Transverse instability of optical spatiotemporal solitons in quadratic media.

• DOI: 10.1103/physrevlett.85.1871
• 发表时间: 2000-08
• 期刊: Physical review letters
• 影响因子: 8.6
• 作者: X. Liu;K. Beckwitt;F. Wise