Development and Characterization of Gallbladder Epithelial Cells

胆囊上皮细胞的发育和表征

• 批准号: nhmrc : 1023060
• 负责人: A/Pr Anand Hardikar
• 金额: $ 48.62万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/development-characterization-gallbladder-epithelial-cells/110241
• 关键词: Development; Characterization; Gallbladder; Epithelial; Cells

Death of insulin-producing cells is a common feature of type 1 and type 2 diabetes, affecting over a million Australians. Although transplantation of cadaveric human islets offers cure, lack of donor islets is a major limitations. An alternative is to find other sources of insulin-producing cells. We are the first to demonstrate that insulin-producing cells are naturally found in human gallbladder. This research proposal will involve detailed characterization of human gallbladder-derived insulin-producing cells.

胰岛素产生细胞的死亡是1型和2型糖尿病的一个共同特征，影响了超过100万澳大利亚人。虽然尸体胰岛移植提供了治愈，缺乏供体胰岛是一个主要的限制。另一种方法是寻找其他产生胰岛素的细胞来源。我们是第一个证明在人类胆囊中天然存在胰岛素产生细胞的人。这项研究计划将涉及人类胆囊源性胰岛素产生细胞的详细特征。