FIELD LIFE Study: Unlocking gene - environment interactions in Type 2 diabetes and its complications

实地生活研究：解开 2 型糖尿病及其并发症的基因-环境相互作用

• 批准号: nhmrc : 1052436
• 负责人: A/Pr Anand Hardikar
• 金额: $ 74.15万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/field-life-study-diabetes-complications/112273
• 关键词: FIELD; LIFE; Study; Unlocking; gene

Genetic and environmental factors influence the risks of developing the blood vessel (vascular), eye and kidney complications of diabetes, but how extensively these factors interact is less well understood. We will examine blood levels of a new class of regulatory molecules (called microRNAs), and of DNA damage and identify how they are linked to vascular risk factors, and heart, foot, eye and kidney damage in 2000 well-characterised Australians with type 2 diabetes from the FIELD Study.

遗传和环境因素会影响糖尿病的血管（血管），眼睛和肾脏并发症的风险，但这些因素如何广泛地相互作用尚不清楚。我们将检查一类新的调节分子（称为microRNA）和DNA损伤的血液水平，并确定它们如何与血管危险因素以及来自FIELD研究的2000名具有良好特征的澳大利亚2型糖尿病患者的心脏，足部，眼睛和肾脏损伤有关。