FIELD LIFE: Lifestyle Interactions in Fenofibrate and the Epigenome

野外生活：非诺贝特和表观基因组的生活方式相互作用

• 批准号: nhmrc : GNT1052436
• 负责人: A/Pr Anand Hardikar
• 金额: $ 71.46万
• 依托单位: University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/field-life-lifestyle-fenofibrate-epigenome/1344527
• 关键词: FIELD; LIFE; Lifestyle; Interactions; Fenofibrate

Genetic and environmental factors influence the risks of developing the blood vessel (vascular), eye and kidney complications of diabetes, but how extensively these factors interact is less well understood. We will examine blood levels of a new class of regulatory molecules (called microRNAs), and of DNA damage and identify how they are linked to vascular risk factors, and heart, foot, eye and kidney damage in 2000 well-characterised Australians with type 2 diabetes from the FIELD Study.

遗传和环境因素影响糖尿病血管、眼睛和肾脏并发症的风险，但这些因素相互作用的程度尚不清楚。我们将检查一种新的调节分子（称为microRNAs）和DNA损伤的血液水平，并确定它们与血管危险因素、心脏、脚、眼睛和肾脏损伤之间的联系。2000年，澳大利亚2型糖尿病患者在FIELD研究中得到了很好的表征。