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Regulation of inflammation by homeostatic cholesterol transport pathways.

通过稳态胆固醇转运途径调节炎症。

基本信息

批准号：
MR/S00968X/1
负责人：
Paras Anand
金额：
$ 62.44万
依托单位：
Imperial College London
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2019
资助国家：
英国
起止时间：
2019 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=MR%2FS00968X%2F1
关键词：
Regulation inflammation homeostatic cholesterol transport

项目摘要

Our body's response to infection and injury is centrally regulated by inflammation, a protective physiological response which is characterized by redness, swelling, heat, and pain, yet helps eliminate infection, clear out dead cells and tissues, and initiate tissue repair. However, perturbations in pathways that control inflammation can give rise to several chronic diseases including atherosclerosis, rheumatoid arthritis, and diabetes amongst others. Therefore, inflammation needs to be tightly regulated. As we age, our ability to regulate different physiological processes, including how we process dietary nutrients, declines, therefore exhibiting metabolic configurations previously unseen by the immune system. Although our understanding of the major drivers of inflammation has increased, however, detailed metabolic pathways that regulate inflammation remain unknown. The main aim of this proposal is to understand how cholesterol metabolism regulates inflammation. Increased cholesterol deposition is often a consequence of sedentary lifestyle and our studies suggest that cholesterol also contributes to the progression of the inflammatory process through mechanisms hitherto unidentified. We will study in-depth how cholesterol drives inflammation and how we may be able to develop treatments to prevent or slow this event. Cholesterol has a significant impact on health and treatment costs because of the associated risk of cardiovascular disease. Thus, understanding the roles of cholesterol in inflammation will help design better strategies to treat disease effectively.

我们身体对感染和损伤的反应由炎症集中调节，炎症是一种保护性生理反应，其特征是发红，肿胀，发热和疼痛，但有助于消除感染，清除死亡细胞和组织，并启动组织修复。然而，控制炎症的通路的扰动可引起几种慢性疾病，包括动脉粥样硬化、类风湿性关节炎和糖尿病等。因此，炎症需要严格控制。随着年龄的增长，我们调节不同生理过程的能力，包括我们如何处理膳食营养素，下降，因此表现出免疫系统以前看不到的代谢结构。尽管我们对炎症的主要驱动因素的理解有所增加，但是，调节炎症的详细代谢途径仍然未知。该提案的主要目的是了解胆固醇代谢如何调节炎症。增加的胆固醇沉积通常是久坐不动的生活方式的结果，我们的研究表明，胆固醇还通过迄今尚未确定的机制促进炎症过程的进展。我们将深入研究胆固醇如何驱动炎症，以及我们如何能够开发治疗方法来预防或减缓这种事件。胆固醇对健康和治疗费用有重大影响，因为它与心血管疾病的风险有关。因此，了解胆固醇在炎症中的作用将有助于设计更好的策略来有效治疗疾病。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

NLRP3 inflammasome priming and activation are regulated by a novel phosphatidylinositol-dependent mechanism

NLRP3 炎症小体启动和激活由一种新型磷脂酰肌醇依赖性机制调节

DOI：
10.1101/2020.01.14.905075
发表时间：
2020
期刊：
影响因子：
0
作者：
Hamilton C
通讯作者：
Hamilton C

Adapt(ed) to repair - TH2 immune responses in the bladder promote recurrent infections.

适应修复 - 膀胱中的 TH2 免疫反应会促进复发性感染。

DOI：
10.1038/s41590-020-0689-2
发表时间：
2020
期刊：
Nature immunology
影响因子：
30.5
作者：
Lukens JR
通讯作者：
Lukens JR

NLRP3 Inflammasome Priming and Activation Are Regulated by a Phosphatidylinositol-Dependent Mechanism.

DOI：
10.4049/immunohorizons.2200058
发表时间：
2022-08-29
期刊：
ImmunoHorizons
影响因子：
0
作者：
Hamilton C;Olona A;Leishman S;MacDonald-Ramsahai K;Cockcroft S;Larrouy-Maumus G;Anand PK
通讯作者：
Anand PK

Fatty acid synthesis promotes inflammasome activation through NLRP3 palmitoylation

DOI：
10.1101/2023.10.30.564549
发表时间：
2023-11
期刊：
bioRxiv
影响因子：
0
作者：
Stuart Leishman;Najd M. Aljadeed;Liyunhe Qian;Shamshad Cockcroft;Jacques Behmoaras;P. Anand
通讯作者：
Stuart Leishman;Najd M. Aljadeed;Liyunhe Qian;Shamshad Cockcroft;Jacques Behmoaras;P. Anand

Right place, right time: localisation and assembly of the NLRP3 inflammasome.