DIET, INFLAMMATION, AND PERIODONTAL DISEASE

饮食、炎症和牙周疾病

• 批准号: 6156426
• 负责人: JAMES S PANKOW
• 金额: $ 4.41万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6156426
• 关键词: acute phase protein; clinical research; dietary constituent; dietary lipid; epidemiology; fish; human subject; inflammation; marine animal oil; nutrition related tag; omega 3 fatty acid; periodontium disorder; prostaglandin E; thromboxanes

The purpose of the proposed research is to investigate the role of habitual dietary intake of fish, n-3 fatty acids of marine origin, and total fat in modifying risk of periodontal disease and the host inflammatory response. The primary goals of this study are to: (a) determine whether greater habitual dietary intake of fish and n-3 fatty acids of marine origin, as determined by food frequency questionnaires, is associated with decreased prevalence, extent, and severity of periodontal conditions in a middle-aged biracial cohort of men and women, (b) determine whether greater dietary intake of fish and n-3 fatty acids of marine origin is originated with reduced levels of prostaglandin E2 and thromboxane B2 measured locally in samples of gingival crevicular fluid, (c) determine whether greater habitual dietary intake of fish and n-3 fatty acids of marine origin is associated with reduced levels of C-reactive of C-reactive protein measured in serum, and (d) determine whether greater habitual dietary intake of total fat is associated with increased levels of prostaglandin E2 measured in gingival crevicular fluid. The study population will be the Atherosclerosis Risk in Communities Study (ARIC), a longitudinal investigation of cardiovascular disease, subclinical atherosclerosis, and associated risk factors in a cohort of 15,792 middle-aged men and women in four U.S. communities This research will take advantage of previously collected information on usual or habitual diet, prevalence, extent, and severity of periodontal conditions and levels of local and systemic inflammatory mediators and markers in members of the ARIC cohort. The proposed research will represent one of the largest epidemiologic studies of diet, periodontal disease, and mediators of inflammation and will provide new dat concerning potentially modifiable risk factors for periodontal disease and other chronic inflammatory conditions.

拟议研究的目的是研究鱼类习惯性饮食摄入，海洋来源的N-3脂肪酸以及总脂肪在改变牙周疾病风险和宿主炎症反应方面的作用。这项研究的主要目标是：（a）确定由食物频率问卷确定的海洋来源的惯常饮食摄入和海洋来源的N-3脂肪酸是否与中等种族歧视同龄人的牙周病的患病率，牙周和牙周病的严重程度的降低有关，男性和女性的中等年龄段（b）确定较高的饮食饮食含量（b），（b）确定较高的饮食酸性生成酸的酸性生成酸的酸性生存源是鱼类和n-3的酸性，这是否存在于鱼类和n-3的脂肪中。 E2和势能箱B2局部在牙龈裂纹液样品中测量，（c）确定对鱼类起源的习惯性饮食摄入和海洋来源的N-3脂肪酸是否与C-反应水平降低相关的C-反应性蛋白质的水平降低相关，并且（d）确定与PREG量相关的习惯水平是否增加了，并且（d）确定效果的量是否会增加。 体液。该研究人群将是社区研究（ARIC）的动脉粥样硬化风险，对心血管疾病的纵向研究，亚级动脉粥样欲ARIC队列成员的标记。拟议的研究将代表饮食，牙周疾病和炎症介质的最大的流行病学研究之一，并将提供有关牙周疾病和其他慢性炎症病的潜在可修改风险因素的新DAT。