Investigating the causal associations of diet and gut microbiome in the development of metabolic disease.

研究饮食和肠道微生物组在代谢疾病发展中的因果关系。

• 批准号: MR/S020039/1
• 负责人: Kanta Chechi
• 金额: $ 36.25万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FS020039%2F1
• 关键词: Investigating; causal; associations; diet; gut

Increased body weight (i.e. obesity) is prevalent not only in the UK but worldwide: 1.9 billion people suffer from overweight and obesity. Obesity often brings along other health conditions like diabetes (422 million people) and heart disease that are responsible for taking the lives of 17.7 million people worldwide every year. Often we think of bad diet and lack of exercise as the main drivers of obesity. But research indicates that other factors like our genes, hormones, immune factors and even the microbes in our gut (i.e. gut microbiome) determine our susceptibility to these conditions by affecting how our body responds to what we eat and how we live. If we can understand how these factors work with each other, we can find ways to prevent and cure obesity and its health consequences. In this project, I will study how our diet and gut microbes are related to obesity, diabetes and heart disease. Using genetic methods applied to population cohorts, I will study if diet can change our gut microbes. I will also look at how our gut microbiome changes with obesity, diabetes and heart disease and finally, I will develop mathematical models to predict whether we can use diet to fix our gut microbes such that we can cure or prevent these conditions. I will also find ways to apply my findings for improving the health of general public at-large.

体重增加（即肥胖）不仅在英国，而且在全世界都很普遍：19亿人患有超重和肥胖。肥胖通常会带来其他健康问题，如糖尿病（4.22亿人）和心脏病，这些疾病每年导致全球1770万人死亡。我们常常认为不良的饮食和缺乏锻炼是肥胖的主要原因。但研究表明，其他因素，如我们的基因、激素、免疫因素，甚至我们肠道中的微生物（即肠道微生物组），通过影响我们的身体对我们的饮食和生活方式的反应，决定了我们对这些疾病的易感性。如果我们能理解这些因素是如何相互作用的，我们就能找到预防和治疗肥胖及其健康后果的方法。在这个项目中，我将研究我们的饮食和肠道微生物与肥胖、糖尿病和心脏病的关系。我将使用应用于人群队列的遗传方法，研究饮食是否可以改变我们的肠道微生物。我还将研究我们的肠道微生物群是如何随着肥胖、糖尿病和心脏病而变化的，最后，我将开发数学模型来预测我们是否可以通过饮食来修复我们的肠道微生物，这样我们就可以治愈或预防这些疾病。我还将设法将我的发现应用于改善广大公众的健康。

项目成果

A prenylated dsRNA sensor protects against severe COVID-19.

• DOI: 10.1126/science.abj3624
• 发表时间: 2021-10-29
• 期刊: Science (New York, N.Y.)
• 作者: Wickenhagen A;Sugrue E;Lytras S;Kuchi S;Noerenberg M;Turnbull ML;Loney C;Herder V;Allan J;Jarmson I;Cameron-Ruiz N;Varjak M;Pinto RM;Lee JY;Iselin L;Palmalux N;Stewart DG;Swingler S;Greenwood EJD;Crozier TWM;Gu Q;Davies EL;Clohisey S;Wang B;Trindade Maranhão Costa F;Freire Santana M;de Lima Ferreira LC;Murphy L;Fawkes A;Meynert A;Grimes G;ISARIC4C Investigators;Da Silva Filho JL;Marti M;Hughes J;Stanton RJ;Wang ECY;Ho A;Davis I;Jarrett RF;Castello A;Robertson DL;Semple MG;Openshaw PJM;Palmarini M;Lehner PJ;Baillie JK;Rihn SJ;Wilson SJ
• 通讯作者: Wilson SJ

SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination.

• DOI: 10.1016/j.ebiom.2022.104402
• 发表时间: 2023-01
• 期刊: EBIOMEDICINE
• 影响因子: 11.1
• 作者: Liew, Felicity;Talwar, Shubha;Cross, Andy;Willett, Brian J.;Scott, Sam;Logan, Nicola;Siggins, Matthew K.;Swieboda, Dawid;Sidhu, Jasmin K.;Efstathiou, Claudia;Moore, Shona C.;Davis, Chris;Mohamed, Noura;Nunag, Jose;King, Clara;Thompson, A. A. Roger;Rowland-Jones, Sarah L.;Docherty, Annemarie B.;Chalmers, James D.;Ho, Ling-Pei;Horsley, Alexander;Raman, Betty;Poinasamy, Krisnah;Marks, Michael;Kon, Onn Min;Howard, Luke;Wootton, Daniel G.;Dunachie, Susanna;Quint, Jennifer K.;Evans, Rachael A.;V. Wain, Louise;Fontanella, Sara;Silva, Thushan I. de;Ho, Antonia;Harrison, Ewen;Baillie, J. Kenneth;Semple, Malcolm G.;Brightling, Christopher;Thwaites, Ryan S.;Turtle, Lance;Openshaw, Peter J. M.
• 通讯作者: Openshaw, Peter J. M.

SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.

• DOI: 10.1016/j.cell.2021.12.046
• 发表时间: 2022-02-03
• 期刊: Cell
• 影响因子: 64.5
• 作者: Dejnirattisai W;Huo J;Zhou D;Zahradník J;Supasa P;Liu C;Duyvesteyn HME;Ginn HM;Mentzer AJ;Tuekprakhon A;Nutalai R;Wang B;Dijokaite A;Khan S;Avinoam O;Bahar M;Skelly D;Adele S;Johnson SA;Amini A;Ritter TG;Mason C;Dold C;Pan D;Assadi S;Bellass A;Omo-Dare N;Koeckerling D;Flaxman A;Jenkin D;Aley PK;Voysey M;Costa Clemens SA;Naveca FG;Nascimento V;Nascimento F;Fernandes da Costa C;Resende PC;Pauvolid-Correa A;Siqueira MM;Baillie V;Serafin N;Kwatra G;Da Silva K;Madhi SA;Nunes MC;Malik T;Openshaw PJM;Baillie JK;Semple MG;Townsend AR;Huang KA;Tan TK;Carroll MW;Klenerman P;Barnes E;Dunachie SJ;Constantinides B;Webster H;Crook D;Pollard AJ;Lambe T;OPTIC Consortium;ISARIC4C Consortium;Paterson NG;Williams MA;Hall DR;Fry EE;Mongkolsapaya J;Ren J;Schreiber G;Stuart DI;Screaton GR
• 通讯作者: Screaton GR

Advances in the integration of metabolomics and metagenomics for human gut microbiome and their clinical applications

• DOI: 10.1016/j.trac.2023.117248
• 发表时间: 2023-08
• 期刊: TrAC Trends in Analytical Chemistry
• 作者: F. Puig-Castellví;R. Pacheco‐Tapia;Maxime Deslande;Manyi Jia;P. Andrikopoulos;K. Chechi;A. Bonnefond;P. Froguel;M. Dumas

Microbiome and metabolome features of the cardiometabolic disease spectrum.

• DOI: 10.1038/s41591-022-01688-4
• 发表时间: 2022-03
• 期刊: Nature medicine
• 影响因子: 82.9
• 作者: Fromentin S;Forslund SK;Chechi K;Aron-Wisnewsky J;Chakaroun R;Nielsen T;Tremaroli V;Ji B;Prifti E;Myridakis A;Chilloux J;Andrikopoulos P;Fan Y;Olanipekun MT;Alves R;Adiouch S;Bar N;Talmor-Barkan Y;Belda E;Caesar R;Coelho LP;Falony G;Fellahi S;Galan P;Galleron N;Helft G;Hoyles L;Isnard R;Le Chatelier E;Julienne H;Olsson L;Pedersen HK;Pons N;Quinquis B;Rouault C;Roume H;Salem JE;Schmidt TSB;Vieira-Silva S;Li P;Zimmermann-Kogadeeva M;Lewinter C;Søndertoft NB;Hansen TH;Gauguier D;Gøtze JP;Køber L;Kornowski R;Vestergaard H;Hansen T;Zucker JD;Hercberg S;Letunic I;Bäckhed F;Oppert JM;Nielsen J;Raes J;Bork P;Stumvoll M;Segal E;Clément K;Dumas ME;Ehrlich SD;Pedersen O
• 通讯作者: Pedersen O