IDENTIFICATION OF GENETIC MARKERS FOR FOCAL SEGMENTAL GLOMERULOSCLEROSIS

局灶节段性肾小球硬化(FSGS)是一种慢性肾脏疾病。 与HIV-1、海洛因使用和镰状细胞贫血有关 非裔美国人(AA)人口，但通常不是在高加索人。这个 AAS中FSGS的增加表明有一种遗传成分 可能是FSGS易感性的基础。我们目前正在建立 来自三组患者的淋巴母细胞系的基因 利用300个微卫星标记和特定候选基因进行分析。 患者组为：1)100例患有FSGS但未感染HIV的AAA， 2)100名患有FSGS和HIV感染的AA，以及3)200名HIV血清阳性AA 无临床肾脏疾病证据的患者。细胞系有 已经为大约100名第1类和第2类患者建立了这一机制。 3类患者是从1200个患有细胞的AA中确定的 LGD存储库中的行。

Focal segmental glomerulosclerosis (FSGS), a chronic renal disease, is associated with HIV-1, heroin use, and sickle cell anemia within the African-American (AA) population, but not generally in Caucasians. The increased prevalence of FSGS in AAs suggests a genetic component that may underlie predisposition to FSGS. We are currently establishing lymphoblastoid cell lines from three groups of patients for a genetic analysis using 300 microsatellite markers and specific candidate genes. The patient groups are: 1) 100 AAs with FSGS but without HIV infection, 2)100 AAs with FSGS and HIV infection, and 3) 200 HIV seropositive AA patients without evidence of clinical renal disease. Cell lines have been established for approximately 100 patients in categories 1 and 2. Patients in category 3 are being identified from the 1200 AAs with cell lines in the LGD repository.