IDENTIFICATION OF GENETIC MARKERS FOR FOCAL SEGMENTAL GLOMERULOSCLEROSIS

局灶节段性肾小球硬化症遗传标记的鉴定

• 批准号: 6161114
• 负责人: C A WINKLER
• 金额: --
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6161114
• 关键词: African American; HIV infections; disease /disorder proneness /risk; genetic mapping; genetic markers; glomerulosclerosis; histocompatibility gene; human genetic material tag; human population genetics; racial /ethnic difference

Focal segmental glomerulosclerosis (FSGS), a chronic renal disease, is associated with HIV-1, heroin use, and sickle cell anemia within the African-American (AA) population, but not generally in Caucasians. The increased prevalence of FSGS in AAs suggests a genetic component that may underlie predisposition to FSGS. We are currently establishing lymphoblastoid cell lines from three groups of patients for a genetic analysis using 300 microsatellite markers and specific candidate genes. The patient groups are: 1) 100 AAs with FSGS but without HIV infection, 2)100 AAs with FSGS and HIV infection, and 3) 200 HIV seropositive AA patients without evidence of clinical renal disease. Cell lines have been established for approximately 100 patients in categories 1 and 2. Patients in category 3 are being identified from the 1200 AAs with cell lines in the LGD repository.

局灶节段性肾小球硬化症（FSGS）是一种慢性肾脏疾病， 与HIV-1、海洛因使用和镰状细胞性贫血有关， 非裔美国人（AA）人群，但一般不存在于高加索人中。的 AA中FSGS患病率的增加表明遗传成分， 可能是易患FSGS的原因。我们目前正在建立 来自三组患者的淋巴母细胞样细胞系进行遗传学研究 使用300个微卫星标记和特定候选基因进行分析。 患者组为：1）100例FSGS但无HIV感染的AA， 2）100例FSGS和HIV感染的AA，以及3）200例HIV血清阳性AA 无临床肾病证据的患者。细胞系具有 已为1类和2类中的约100名患者建立。 正在从1200例具有细胞的AA中确定第3类患者 LGD仓库中的行。