CMV INFECTIONS IN AIDS PATIENTS ON ANTIVIRAL CLINICAL PROTOCOLS

接受抗病毒临床治疗的艾滋病患者的巨细胞病毒感染

• 批准号: 6101179
• 负责人: J. F MANISCHEWITZ
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6101179
• 关键词: AIDS; AIDS therapy; CD4 molecule; adenine analog; clinical research; clinical trial phase I; cytomegalovirus; cytosine analog; diagnosis quality /standard; diagnostic respiratory lavage; human subject; interferon alpha; interleukin 2; microorganism disease chemotherapy; opportunistic infections; virus classification; zidovudine

(1) Goals of Project: - Since CMV is recognized as one of the leading opportunistic infections in AIDS patients, it is important to monitor blood, urine, and tissue specimens from patients enrolled in various clinical trials for the presence of CMV. - Determine whether elevated CD4 counts resulting from triple therapy against HIV are effective in controlling CMV retinitis. (2) Purpose of Clinical Protocols: To determine whether immune function in HIV-infected individuals with elevated CD4+ counts on potent antiviral therapy is effective in controlling CMV retinitis without specific anti- CMV therapy. Publication in preparation: Successful discontinuation of specific anti-cytomegalovirus therapy in persons with HIV infection and cytomegalovirus retinitis: Results of a longitudinal intervention trial.

(1)项目目标： -由于CMV被认为是主要的机会性感染之一 对于艾滋病患者，监测血液、尿液和组织是很重要的 来自参加各种临床试验的患者的样本 出现巨细胞病毒。 -确定三联疗法是否导致CD4细胞计数升高 抗HIV在控制CMV视网膜炎方面是有效的。 (2)临床方案的目的： 以确定HIV感染者的免疫功能 随着CD4+计数的升高，有效的抗病毒治疗对 控制巨细胞病毒视网膜炎而不进行特定的抗巨细胞病毒治疗。 正在筹备中的出版物：特定出版物成功停刊 HIV感染者和患者的抗巨细胞病毒治疗 巨细胞病毒性视网膜炎：一项纵向干预试验的结果。